小月龄婴儿麻疹发病控制对策探讨

王联君; 孙丽英; 姜忠林; 康顺爱; 刘英; 姜晓春

Abstract

王联君,孙丽英,姜忠林,康顺爱,刘英,姜晓春.小月龄婴儿麻疹发病控制对策探讨[J].Chinese journal of Epidemiology,2001,22(1):49-50

小月龄婴儿麻疹发病控制对策探讨

The study of countermeasures on measles control in infants

Received:March 07, 2000

DOI：

KeyWord: 麻疹抗体婴儿疫苗

English Key Word: Measles Antibody Infant Vaccin

FundProject:

Author Name	Affiliation
WANG Lianjun	Senitation and Anti-epidemic Station of Jilin Province, Changchun 130021, China
SUN Liying	Senitation and Anti-epidemic Station of Jilin Province, Changchun 130021, China
JIANG Zhonglin	Senitation and Anti-epidemic Station of Jilin Province, Changchun 130021, China
KANG Shunai	Senitation and Anti-epidemic Station of Jilin Province, Changchun 130021, China
LIU Ying	四平市卫生防疫站
JIANG Xiaochun	东辽县卫生防疫站

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Abstract:

目的: 了解育龄妇女、新生儿麻疹抗体水平及其关系，婴儿胎传抗体衰减情况，不同月龄婴儿对麻疹疫苗的免疫应答情况，探讨减少小月龄麻疹病例的对策。方法: 采用ELISA方法测定血清中麻疹IgG抗体水平。结果: 58对育龄妇女及其婴儿中有 51对麻疹抗体相同，7对不同，但只相差 1个滴度，且两者抗体均处于低水平。通过对胎传抗体追踪观察发现，新生儿抗体水平不高，3月龄时降低 50%，6月龄和 8月龄降到 15%左右，抗体水平很低，几乎无保护作用，且 6月龄和 8月龄婴儿接种疫苗后免疫成功率间无差别。结论: 说明母婴麻疹抗体间有密切关系，由于目前育龄妇女麻疹抗体水平低，因此，可通过对育龄妇女接种麻疹疫苗来提高婴儿抗体水平，同时建议在某些地区将麻疹初免时间从 8月龄提前到 6月龄时进行。

English Abstract:

Objective: To understand: a) measles antibody levels in puerpera and their new borns, and the relation between them, b ) maternal transferred measles antibody level of different age group infants, c) immunization rates of success in 6 and 8 month old infants, d) to study measles control countermeasures on infants. Methods: To test measles IgG antibody levels of infant's blood using ELISA method. Results: Antibody levels of measles in 58 pairs of mother and their newborns, 51 pairs were the same, while 7 pairs were different. Measles antibody levels in newborns was not high and reduced to 50% in 3 mo nths, 20% in 6 months, and 15% in 8 months. The antibody levels in 6 and 8 month olds werelow, nearly no protection to children. It was found that rates of immunization success and the antibody distribution were not statistically different between 6 and 8 months olds after measles vaccination. Conclusion: It was found that the measles antibody level in most matured women was low. Since mother's measles antibody level has close relation to their newborns, it seems that the newborn's antibody level canbe improved by vaccination to matured women. In order to reduce morbidity of infant measles, the age of first vaccination of measles vaccine should be changed from 8 months old to 6 months old in some regions.

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