程均福,秦进才,谢广中,张流波,张锦麟,丁建平,严有望,张新炳.钩端螺旋体外膜菌苗流行病学效果研究[J].Chinese journal of Epidemiology,2001,22(2):108-110 |
钩端螺旋体外膜菌苗流行病学效果研究 |
Epidemiological observation on effect of Leptospiral outer membrane vaccine |
Received:October 30, 2000 |
DOI: |
KeyWord: 钩端螺旋体外膜菌苗 流行病学效果 |
English Key Word: Leptospiral outer membrane vancine Epidemiological efficacy |
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Abstract: |
目的证实钩端螺旋体外膜菌苗的安全性和免疫效果。方法在湖北省荆州市和石首市现场接种钩端螺旋体外膜菌苗80000人份,观察48h内体温、局部红肿等副反应和一年内接种钩端螺旋体外膜菌苗者发病情况,同时设对照组。结果所有钩端螺旋体外膜菌苗接种者未见严重副反应和异常反应,仅2例菌苗接种者有低热和局部红肿,48h后消失,安全性良好。接种组发生黄疸出血群钩端螺旋体病人2例,对照组发生黄疸出血群钩端螺旋体病人47例,黄疸出血群钩端螺旋体外膜菌苗保护效果95.57%,95%可信限为85.43%~98.20%;对照组发生七日热群钩端螺旋体病人15例,七日热群钩端螺旋体外膜菌苗有效率100.00%,95%可信限下限77.08%。结论钩端螺旋体外膜菌苗安全性良好,接种与疫区流行菌群一致的钩端螺旋体外膜菌苗,可以取得较好的免疫保护效果。 |
English Abstract: |
Objective To study the safety and effect of Leptospiral outer membrane vaccine. Methods Eighty thousandsdosagesof Leptospiral outer membrane vaccine were vaccinated in Jingzhou and Shishou city Hubei prevince.Temperaure, side -effects such as Local edema with in 48 hours as well as the incidence of Leptospirsis within a year among those were vaccinated and unvaccinated were observed. Results ( 1) No any severe side -effect and abnormal reaction, was found, only 2 case suffered from slight fever and local edema which receded in 48 hrs. ( 2)Effects of Leptospiral outer membrane vaccine were as follows: 2 cases were attacked by lcterohaemorrhagiae in vaccination group and 47 cases in control group, so the protection rate 95. 57%and confidence interval( CI)was 85. 43% -98. 20%. Fifteen hebdomadis cases were found in control group.The protection rate of this vaccine reached 100. 00%, CI 77. 08% -100. 00%. Conclusion Safty and protective effect were wellshowed when type of bacteria was concordant with that in vaccination district |
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