| 程均福,秦进才,谢广中,张流波,张锦麟,丁建平,严有望,张新炳.钩端螺旋体外膜菌苗流行病学效果研究[J].Chinese journal of Epidemiology,2001,22(2):108-110 |
| 钩端螺旋体外膜菌苗流行病学效果研究 |
| Epidemiological observation on effect of Leptospiral outer membrane vaccine |
| Received:October 30, 2000 |
| DOI： |
| KeyWord: 钩端螺旋体外膜菌苗 流行病学效果 |
| English Key Word: Leptospiral outer membrane vancine Epidemiological efficacy |
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| Abstract: |
| 目的证实钩端螺旋体外膜菌苗的安全性和免疫效果。方法在湖北省荆州市和石首市现场接种钩端螺旋体外膜菌苗80000人份，观察48h内体温、局部红肿等副反应和一年内接种钩端螺旋体外膜菌苗者发病情况，同时设对照组。结果所有钩端螺旋体外膜菌苗接种者未见严重副反应和异常反应，仅2例菌苗接种者有低热和局部红肿，48h后消失，安全性良好。接种组发生黄疸出血群钩端螺旋体病人2例，对照组发生黄疸出血群钩端螺旋体病人47例，黄疸出血群钩端螺旋体外膜菌苗保护效果95.57%，95%可信限为85.43%～98.20%;对照组发生七日热群钩端螺旋体病人15例，七日热群钩端螺旋体外膜菌苗有效率100.00%，95%可信限下限77.08%。结论钩端螺旋体外膜菌苗安全性良好，接种与疫区流行菌群一致的钩端螺旋体外膜菌苗，可以取得较好的免疫保护效果。 |
| English Abstract: |
| Objective To study the safety and effect of Leptospiral outer membrane vaccine. Methods Eighty thousandsdosagesof Leptospiral outer membrane vaccine were vaccinated in Jingzhou and Shishou city Hubei prevince.Temperaure, side -effects such as Local edema with in 48 hours as well as the incidence of Leptospirsis within a year among those were vaccinated and unvaccinated were observed. Results ( 1) No any severe side -effect and abnormal reaction, was found, only 2 case suffered from slight fever and local edema which receded in 48 hrs. ( 2)Effects of Leptospiral outer membrane vaccine were as follows: 2 cases were attacked by lcterohaemorrhagiae in vaccination group and 47 cases in control group, so the protection rate 95. 57%and confidence interval( CI)was 85. 43% -98. 20%. Fifteen hebdomadis cases were found in control group.The protection rate of this vaccine reached 100. 00%, CI 77. 08% -100. 00%. Conclusion Safty and protective effect were wellshowed when type of bacteria was concordant with that in vaccination district |
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