| 张扬,陈坤,张海蕾,朱益民.非吸烟女性肺癌发病危险因素的Meta分析[J].Chinese journal of Epidemiology,2001,22(2):119-121 |
| 非吸烟女性肺癌发病危险因素的Meta分析 |
| Meta -analysis of risk factors on lung cancer in non -smoking Chinese female |
| Received:October 12, 2000 |
| DOI： |
| KeyWord: 女性肺癌 危险因素 比值比 Meta分析 |
| English Key Word: Female lung cancer Risk factor OR Meta -analysis |
| FundProject: |
| Author Name | Affiliation | | ZHANG Yang | Department of Epidemiology, The Affiliated Medical College of Zhejiang University, Hangzhou 310006, China | | CHEN Kun | Department of Epidemiology, The Affiliated Medical College of Zhejiang University, Hangzhou 310006, China | | ZHANG Hailei | Department of Epidemiology, The Affiliated Medical College of Zhejiang University, Hangzhou 310006, China | | ZHU Yimin | Department of Epidemiology, The Affiliated Medical College of Zhejiang University, Hangzhou 310006, China |
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| Abstract: |
| 目的综合评价我国非吸烟女性肺癌发病的危险因素。方法应用Meta分析方法对国内7篇有关非吸烟女性肺癌危险因素的病例对照研究进行定量综合分析，共累积病例1115例，对照1520例。统计处理采用Meta分析的随机效应模型。结果肺部疾病史、家族肺癌史、油烟污染、煤烟污染、被动吸烟等5个研究因素的合并比值比(OR值)分别是2.87、2.79、2.52、1.42和1.64,进一步分层研究提示随着油烟污染程度的加重，其OR值也有明显的上升。结论家族肺癌史、肺部疾病史、油烟污染、煤烟污染等因素可能与非吸烟女性肺癌的发生有关，被动吸烟的作用尚不能肯定。 |
| English Abstract: |
| Objective To evaluate the risk factors of lung cancer in non-smoking Chinese women.Methods The results of 7 case -control studies from 1990 to 1999 were analyzed by Meta -analysis method in this study.The cumulative cases and controls were 1 115 and 1 520, respectively.Der Simonian and Nan Laid model were applied to process data.Results The pools OR values of family history of lungcancer, personal history of non -neoplastic lung disease, cooking oil fume pollution, coal pollution and exposure to environmental tobacco smoking ( ETS)were 2. 87, 2. 79, 2. 52, 1. 42 and 1. 64 respectively.Conclusion Family history of lung cancer and personal history of non-neoplastic lung disease might serve as the most important risk factors of female lung cancer in China.There appeared also significantly positive relationship between female lung cancer and the degree of cooking oil fume pollution or pollution of coal burning.The effect on lung cancer of exposure to ETS was uncertain in this study which calls for further investigation. Bias and confounding factors were also discussed in this study |
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