| 胡蓉,曹务春,张习坦.部队乙型肝炎疫苗预防接种的成本效果分析[J].Chinese journal of Epidemiology,2001,22(2):142-145 |
| 部队乙型肝炎疫苗预防接种的成本效果分析 |
| Cost -effectiveness analysis of hepatitis B vaccination in People ' s Liberation Army |
| Received:October 23, 2000 |
| DOI： |
| KeyWord: 乙型肝炎疫苗接种 成本效果分析 失能调整生命年 |
| English Key Word: Hepatitis B vaccination Cost-effectiveness analysis Disability-adjusted life year( DALY) |
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| Abstract: |
| 目的应用成本效果分析对部队不同乙型肝炎(乙肝)疫苗接种方案进行比较，为制定经济有效的全军乙肝疫苗预防接种策略提供依据。方法建立决策树和乙肝转归树，采用催化模型推算不同接种方案下易感人群年新感染率，用失能调整生命年(disabilityadjustedlifeyear，DALY)作为衡量效果的指标，计算增量成本效果比。结果与不接种方案相比，直接接种方案和筛检再接种方案的DALY分别为61.888和57.175，增量成本效果比(costeffectivenessratio，CER)分别为392.70和251.90。用部队干部实际年龄构成进行加权，得到筛检再接种方案和直接接种方案的CER分别为251.9和392.7,即每获得一个健康生命年所需成本前者少于后者。结论筛检再接种方案优于直接接种方案;年龄越小接种的效果越好。 |
| English Abstract: |
| Objective To select an optimal vaccination approach and provide basis for decision-making on the control of hepatitis B infection in PLA.Methods Decision trees were constructed.The yearly new infection rate in susceptible cohort, using a catalytic model, was estimated.Disability-adjusted life year( DALY)was used to assess the effectiveness. Incremental cost-effectiveness ratio ( CER )was thencalculated.Results Compared with no vaccination, DALY of immediate vaccination and vaccination after screening were 61. 89 and 57. 18 with CER 392. 70 and 251. 90 respectively. After weighting with actual age construction of PLA population, the CERs of vaccination after screening and immediate vaccination were 251. 90 and 392. 70 respectively.Conclusion The results indicated that screening followed byvaccination was superior to immediate vaccination approach.The younger the vaccination was carried out,the more cost -effective was shown by vaccination. |
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