广东省揭阳市居民食管癌发病危险因素的
病例对照研究

张稳定; 安丰山; 林汉生; 余华斐; 陈少湖; 王声涌

Abstract

张稳定,安丰山,林汉生,余华斐,陈少湖,王声涌.广东省揭阳市居民食管癌发病危险因素的病例对照研究[J].Chinese journal of Epidemiology,2001,22(6):442-445

广东省揭阳市居民食管癌发病危险因素的病例对照研究

A case-control study on the risk factors of esophageal cancer in Jieyang city of Guangdong in China

Received:April 20, 2001

DOI：

KeyWord: 食管肿瘤病例对照研究流行病学

English Key Word: Esophageal neoplasms Case-control study Epidemiology

FundProject:广东省科委重点科研基金资助项目(1998071)

Author Name	Affiliation	E-mail
ZHANG Wending	Guangdong Provincial Science and Research Center of Esophageal Cancer, Jieyang Municipal People' s Hospital, Jieyang 522000, China
AN Fengshan	Guangdong Provincial Science and Research Center of Esophageal Cancer, Jieyang Municipal People' s Hospital, Jieyang 522000, China
LIN Hansheng	暨南大学医学院预防医学教研室
余华斐	Guangdong Provincial Science and Research Center of Esophageal Cancer, Jieyang Municipal People' s Hospital, Jieyang 522000, China
陈少湖	Guangdong Provincial Science and Research Center of Esophageal Cancer, Jieyang Municipal People' s Hospital, Jieyang 522000, China
王声涌	暨南大学医学院预防医学教研室	wangshengyong @163.net

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Abstract:

目的　筛选广东省揭阳市食管癌的危险因素。方法　1999 年在揭阳市人民医院接受治疗的214 例食管癌和贲门癌病人纳入病例组，均经过病理学诊断：214 名健康人作为对照组，按病例组的性别、年龄和居住地(镇)的构成情况从人群中随机抽取。研究对象均在揭阳市居住20 年以上，用统一的调查表进行问卷调查。用非条件logistic 回归进行多因素分析。结果　主要的危险因素是饮烫茶(OR ：1.39 ～ 3.74)、吃饭快(OR :1.54～ 4.10)、吃硬饭(OR :1.32 ～ 4.27)、猪油(OR :3.57 ～42.03)和肉类(OR :1.36～ 5.05)：保护性因素是饮用自来水20 年以上(OR :0.13 ～ 0.51)。未发现吸烟史、食管癌家族史与食管癌有关联。结论　本研究筛选出的因素普遍暴露于揭阳市居民中。多数因素与其他地区的同类研究一致，但猪油和肉类是本研究中提出的影响因素，有待于实验研究证实。

English Abstract:

　Objective　To study the risk factors o f esophag eal cancer in Jieyang city of Guangdong province.Methods　Two hundred and fourteen cases with pathological diagnosis of esophageal cancer were recruited at Jieyang Municipal People' s Hospital in 1999.Tw o hundred and four teen co ntrols w ere selected f rom healthy residents matched with sex, age and residential places (town) of the cases.All cases and controls had resided in Jieyang city for over 20 years and were studied through a uniformed questionnaire.Non-nditional logistic regression was used for multivariate analy sis.Results The impo rtant risk factors were ov er-hot tea drinking habit (OR :1.39-3.74), fast eating (OR :1.54-4.10),animal oil (OR :3.57-42.03)and meat consumptio n (OR :1.36-5.05)while the pro tective facto rs were tap water (OR :0.13-0.51) drinking habil for over 20 years.Histo ries of smoking and family eso phag eal cancer w ere no t significantly correlated with esophageal cancer.Conclusion　The risk facto rs revealed in this study were commonly ex posed to the residents of Jieyang city.Most of the factors were in agreement to the results f rom o ther similar studies, but the factors of animal oil and meat were unique in this study, w hich called fo r further studies

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