| 黄勤,金若红,邹大进,薛广波,肖红,顾春英,张文光,张丽梅,王丽琼,朱慧琪,蔡明江.碘摄入量增加后甲状腺疾病发病率的变化[J].Chinese journal of Epidemiology,2001,22(6):455-458 |
| 碘摄入量增加后甲状腺疾病发病率的变化 |
| Study on the effects of increased iodized salt intake on the incidence of thyroid diseases?? |
| Received:April 01, 2001 |
| DOI： |
| KeyWord: 碘盐 甲状腺疾病 流行病学 |
| English Key Word: Iodized salt Thyroid disease Epidemiology |
| FundProject:国家自然科学基金资助项目 (39500072) 江苏省教委科研基金资助项目 (99KJB320002) |
| Author Name | Affiliation | | HUANG Qin | Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China | | JIN Ruohong | 宝钢集团果园中心门诊部 | | ZOU Dajin | Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China | | 薛广波 | 第二军医大学流行病学教研室 | | 肖红 | 宝钢集团果园中心门诊部 | | 顾春英 | 第二军医大学流行病学教研室 | | 张文光 | Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China | | 张丽梅 | Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China | | 王丽琼 | Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China | | 朱慧琪 | Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China | | 蔡明江 | Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China |
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| Abstract: |
| 目的?? 观察食用碘盐应用前后甲状腺疾病谱的变化。方法?? 采用问卷形式自1999 年8 月中旬至12 月底共调查宝钢集团26 010人。结果?? ?? 1990 年1 月1 日至1999 年7 月31 日确诊的甲状腺疾病患者共310 例, 其中食盐加碘后3 年半内新发病183 例, 较前6 年明显增多。?? 甲状腺疾
病谱构成发生了明显改变, 主要表现在甲状腺功能亢进( 甲亢) 、单纯性甲状腺肿大及甲状腺结节( B超检查) 患者明显增多。尽管甲状腺结节的发病率仍高居第一位, 但甲亢的发病率由补碘前的第五位上升至第二位。?? 近10 年新确诊的甲亢患者55 例, 其中39 例补碘后发病, 占70. 91%; 补碘后甲亢平均发病率为36. 87/ 10 万人年?? 5. 40/ 10 万人年, 较前增加3 倍; 补碘后当年甲亢发病率即开始明显升高, 1997 年最高, 以后仍维持在较高水平; 补碘后各年甲亢发病相对危险度均有不同程度的升高。结论?? 随着食用碘盐的应用, 调查人群甲状腺疾病患者明显增多, 甲状腺疾病谱构成也发生了明显改变, 尤其是甲亢发病率明显增高, 与碘摄入量增多明显相关。但补碘后各种甲状腺疾病发病率变化的
最终模式仍有待进一步观察。 |
| English Abstract: |
| Objective?? To study the annual incidence of t hyr oid diseases before and after the increase of iodized salt intake. Method?? A total of 26 010 persons were examined from mid August to the end of December in 1999. Results ?? ?? Three hundred and ten patients of thyroid diseases were ident ified fr om 1990 to July 1999. One hundr ed and eighty- three patients were diagnosed after iodine supplementation. T he constitution of thy roid diseases had changed significantly regarding the increase of hyperthyroidism,simple goiter and thyroid nodule. ?? Fifty-fiv e patients with hy perthyroidism including 39 patients ( 70. 91%) receiving iodine supplementation were diagnosed. The average annual incidence of
hyper thy roidism after iodine supplementatio n was 36. 87 per 100 000, a three- time increase as compared
w ith that before iodine supplementation. T he incidence of hypert hyro idism began to show a sig nificant r ise in 1996. The year w ith hig hest annual incidence was 1997, r emaining at high level after supplying iodized salt. Since then t he annual relat ive r isk for hyperthyroidism had been increasing. Conclusion?? T he number of pat ients w ith t hyr oid diseases show ed a sig nificant incr ease after mass iodine supplement. At the same t ime, the spectrum o f thyroid diseases had also changed. Iodized salt intake and the incidence of
hyper thy roidism showed a significant correlation. How ever, the typical model of the change of disease
patter ns incidence needs further study |
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