阿尔茨海默病与家族史病例对照研究

姚佳红; 李辉; 张振馨

Abstract

姚佳红,李辉,张振馨.阿尔茨海默病与家族史病例对照研究[J].Chinese journal of Epidemiology,2002,23(1):54-56

阿尔茨海默病与家族史病例对照研究

A case-control study on family history of Alzheimer's disease

Received:May 24, 2001

DOI：

KeyWord: 阿尔茨海默病家族史病例对照研究

English Key Word: Alzheimer's disease Family history Case-control study

FundProject:

Author Name	Affiliation
YAO Jiahong	epartment of Epidemiology Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China
LI Hui	epartment of Epidemiology Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China
ZHANG Zhenxin	epartment of Epidemiology Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China

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Abstract:

目的探讨家族史和阿尔茨海默病(AD)的关系。方法采用以人群为基础的病例对照研究设计,病例组为127例临床诊断为AD的病例,并以1∶2配对,以年龄、性别、受教育程度为匹配条件的254名非痴呆者作为对照,通过单因素分析和条件logistic回归分析,估计AD与家族史之间的联系强度。结果一级亲属有痴呆病史或重性精神病史者,患AD危险性显著高于对照人群(OR值分别为6.25和8.33,P<0.01)。调整混杂因子的影响后,一级亲属的痴呆家族史和AD的发生仍有显著联系(调整后OR=2.07,P=0.018)。结论AD可能存在家族史聚集性。

English Abstract:

Objective To explore the relationship between Alzheimer's disease and its family history of the patients. Methods Stratified analyses and logistic regression analysis were used to examine the association between Alzheimer's disease and its family history exposure in 127 cases and 254 matched controls from a population-based case-control study. Results The risk of Alzheimer's disease was significantly higher in those who had at least one first-degree relative with dementia or major psychosis as compared to those who had no dementia or major relatives with psychosis (OR= 6.25; 8.33). Adjusted for age and level of education, family history of dementia was still associated with Alzheimer's disease positively (OR= 2.07).ConclutionThis study provides evidence that familial aggragation of Alzheimer's disease might txst among people living Beijing.

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