福州市健康儿童口咽部流感嗜血杆菌带菌情况调查

赖国祥; 张鸿文; 叶礼燕; 黄梁浒; 林茂英; 曹慧琴; 陈新民

Abstract

赖国祥,张鸿文,叶礼燕,黄梁浒,林茂英,曹慧琴,陈新民.福州市健康儿童口咽部流感嗜血杆菌带菌情况调查[J].Chinese journal of Epidemiology,2002,23(2):108-110

福州市健康儿童口咽部流感嗜血杆菌带菌情况调查

Study on the status of oral pharyngeal carriage of Haemophilus influenzae in healthy preschool children in Fuzhou city

Received:June 20, 2001 Revised:August 06, 2012

DOI：

KeyWord: 流感嗜血杆菌儿童携带率

English Key Word: Haemophilus influenzae Children Carriage rate

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Author Name	Affiliation
LAI Guoxiang	Department of Respiratory Disease. Fuzhou Military General Hospital, Fuzhou 350025, China
ZHANG Hongwen	Department of Respiratory Disease. Fuzhou Military General Hospital, Fuzhou 350025, China
YE Liyan	南京军区福州总医院儿科
HUANG Lianghu	南京军区福州总医院检验科
LIN Maoying	南京军区福州总医院儿科
CAO Huiqin	南京军区福州总医院儿科
CHEN Xinmin	南京军区福州总医院儿科

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Abstract:

目的了解福州市健康儿童口咽部流感嗜血杆菌 (Haemophilusinfluenzae,Hi)带菌情况及菌型特点,提供Hi感染的临床防治依据。方法选择福州市具有代表性的两所日托幼儿园健康儿童 6 0 3名,进行口咽部Hi携带率四季监测,Hi分离株进一步作血清学分型及生物学分型。结果日托健康儿童口咽部Hi携带率以冬季最高 (36.7%),秋季次之 (18.0 %),春季 (10.9%)和夏季(12.4 %)相近。Hi分离株血清型秋季以Hib携带率最高 (6.9%),冬季以不可分型Hi(NTHi)为主,携带率占 17.1%,Hib携带率 5.4 %,秋、冬季其他各血清型携带率较低。Hi分离株生物型在秋、春、夏季分布较为一致,以生物Ⅶ、Ⅷ型占优势 ;冬季生物Ⅶ、Ⅷ型明显减少。结论健康儿童口咽部Hi定殖菌携带率及菌型有季节变迁现象,以冬、秋季Hi携带率较高。提示,在重视Hib结合菌苗接种的同时,应加强Hi新型菌苗的研究。

English Abstract:

Objective To study the status of oral pharyngeal carriage and characteristics of Haemophilus influenzae (Hi) in healthy preschool children in Fuzhou. Methods Six hundred and three healthy children in two representative kindergartens in Fuzhou were studied as research subjects, and the rates of oral pharyngeal carriage of Hi were studied in four seasons. All Hi strains were serotyped and biotyped. Results The oral pharyngeal carriage of Hi in day care nursery healthy children were 36.7 % in winter, 18.0 % in autumn, 12.4 % in summer and 10.9 % in spring respectively. Serotype Hib was preponderant in autumn (6.9 %). In winter, the carriage rates of NTHi and Hib were 17.1 %, 5.4 % respectively. The carriage rates of other serotypes were low. Biotype Ⅶ and Ⅷ were preponderant in autumn, spring and summer but biotype Ⅶ and Ⅷ were decreasing evidently in winter. Conclusion There was evident seasonal difference in the rates of oral pharyngeal carriage and type of Hi in healthy preschool children. The carriage rate of Hi strains was high in autumn and winter. Results suggested that while the inoculation of Hib binding bacterial vaccine was expanded the study on new bacterial vaccine of Hi still needs to be augmented.

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