| 陈进,王家良,李宁秀,章茂顺,符宗胤,张兰,尹国玲,吴泰相.非药物干预对高脂血症患者降脂效果研究[J].Chinese journal of Epidemiology,2002,23(2):138-141 |
| 非药物干预对高脂血症患者降脂效果研究 |
| The effects of non-pharmacotherapy in decreasing the levels of serum lipid in patients with hyperlipidemia |
| Received:November 05, 2001 |
| DOI： |
| KeyWord: 高脂血症 非药物干预 生活方式 饮食行为 |
| English Key Word: Hyperlipidemia Non pharmacotherapy Life style Diet behavior |
| FundProject:国际临床流行病学网(INCLEN)资助项目(洛2300411);四川省卫生厅资助项目(F981059) |
| Author Name | Affiliation | | CHEN Jin | Department of Clinical Epidemiology, Huaxi Hospital, Sichuan University, Chengdu 610041, China | | WANG Jialiang | Department of Clinical Epidemiology, Huaxi Hospital, Sichuan University, Chengdu 610041, China | | LI Ningxiu | 四川大学社会医学教研室 | | ZHANG Maoshun | 四川大学华西医院干部病房 | | FU Zongyin | 四川省教育厅 | | ZHANG Lan | 成都理工学院校医院 | | YIN Guoling | 四川省工业学院校医院 | | WU Taixiang | Department of Clinical Epidemiology, Huaxi Hospital, Sichuan University, Chengdu 610041, China |
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| Abstract: |
| 目的 探讨非药物干预对高脂血症患者的降脂效果。方法 采用组群干预试验。干预组给予每周 1次,连续 6周的高脂血症非药物干预,包括高脂血症相关的健康知识、改变饮食和不良生活方式等具体指导 ;两周一次的门诊随访等。对照组不给予上述干预措施。两组观察期均为 6个月,观察期间不使用降脂药。在入组时和干预后 6个月分别测定血脂、血糖、体重、血压及高脂血症的知识水平、饮食和运动情况指标。结果 干预组 15 4例,对照组 15 0例纳入分析。干预后干预组的高脂血症相关的知识水平较对照组明显增加 [2 2.5 (4.8),17.4 (4.2) (95 %CI:4.1,6.1) ];干预组中饮食积分和参加运动的比例分别增加了 2 7.2 0 %,2 1.78% ;血甘油三酯 (TG)、血总胆固醇 (TC)和体重指数 (BMI)干预组较对照组有明显降低 [干预组分别为 :2.0 (0.9)mmol/L,5.4 (0.9)mmol/L,2 3.4(1.9),对照组分别为 :2.4 (0.9)mmol/L,5.9(1.0)mmol/L,2 4.2 (3.0) ]。结论 本研究对高脂血症患者的非药物干预方法是有效的。经过非药物干预效果不显著的病例采用降脂药物治疗是必要的,但非药物干预应作为基础治疗 |
| English Abstract: |
| Objective To develop a non pharmacotherapy program for patients with hyperlipidemia and assess its effectiveness. Methods A cluster control trial was used. The experimental group was given non pharmacotherapy for hyperlipidemia once a week for 6 weeks; the content of non pharmacotherapy included the basic knowledge about hyperlipidemia, a guide of changing unhealthy diet and life style. Patients were followed for once every two weeks in the department of out patient. The control group received general care conducted by university clinicians, without the non pharmacotherapy program. A self completion questionnaire on hyperlipidemia related knowledge level, questionnaires on diet and exercise, body weight, body height and the serum TG, TC were measured at entry point and at the end of 6 month. Results One hundred and fifty four patients in experimental group and 150 patients in control group completed the study. The non pharmacotherapy group showed a significant increase of knowledge on hyperlipidemia in the experimental group comparing with the control group: the mean (sd) score of hyperlipidemia related knowledge were 22.5 (4.8), 17.4 (4.2)(95% CI : 4.1, 6.1). The diet score and the proportion of regular physical activity had increased 27.20 %, 21.78 % respectively in experimental group. The mean (sd) of serum TG, TC and body mass index (BMI) for experimental group [ 2.0 (0.9) mmol/L, 5.4 (0.9) mmol/L, 23.4 (1.9)] lowered significantly comparing to those for control group [ 2.4 (0.9) mmol/L, 5.9 (1.0) mmol/L, 24.2 (3.0)]. Conclusion Non pharmacotherapy seemed to be an important intervention for the patients with hyperlipidemia. If same patients with hyperlipidemia failed to respond to non pharmacotherapy, it is necessary to use pharmacotherapy. However, non pharmacotherapy should be viewed as basic therapy. |
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