| 郑玉新,冷曙光,宋文佳,王雅文,牛勇,张文众,闫惠芳,刘玉瑛,黄清霄,吴宜群.重度铅污染地区儿童铅中毒的分子流行病学研究[J].Chinese journal of Epidemiology,2002,23(3):175-178 |
| 重度铅污染地区儿童铅中毒的分子流行病学研究 |
| A molecular epidemiological study of childhood lead poisoning in lead-polluted environment |
| Received:November 30, 2001 |
| DOI： |
| KeyWord: 铅中毒 遗传易感性 流行病学 分子 |
| English Key Word: Lead poisoning I nherited susceptibility Epidemiology molecular |
| FundProject:国家“九五”科技攻关项目(96-920-26-03) |
| Author Name | Affiliation | | ZHENG Yuxin | Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | LENG Shuguang | Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | SONG Wenjia | Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | WANG Yawen | Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | NIU Yong | Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | ZHANG Wenzhong | Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | YAN Huifang | Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | LIU Yuying | Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | HUANG Qingxiao | Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China | | WU Yiqun | Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China |
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| Abstract: |
| 目的 研究高暴露于铅的条件下, δ-氨基乙酰丙酸脱水酶(ALAD)和维生素D受体(VDR)基因多态性对儿童铅中毒易感性的影响. 方法 分析了469名严重铅暴露儿童ALAD和VDR基因多态性、血铅、锌原卟啉(ZPP)、头围、身高和体重等指标. 结果 具有ALAD2等位基因个体, 血中ZPP水平高于不含该等位基因的个体(P=0. 017);携带VDRB等位基因个体的头围大于仅携带b等位基因者(51. 19cm和50. 75cm)(P=0. 028). 结论 在高水平铅暴露儿童中, ALAD多态性可影响铅的血液毒性效应, VDR基因的遗传变异改变铅对儿童颅骨发育的作用程度. ALAD和VDR基因多态性是影响严重铅暴露条件下儿童铅中毒易感性的分子遗传学因素. |
| English Abstract: |
| Objective The relationship between polymorphisms of ALAD and VDR genes and individual susceptability of lead poisoning was investigated in children highly exposed to lead. Method Four hundred and sixty nine children were recruited into this study and the blood lead, ZPP, hemoglobin as well as three physical developmental indexes (head circumference, height and weight) were measured. VDR and ALAD gene polymorphisms were analyzed by the Methods of PCR RFLP. Results The subjects with ALAD2 allele had higher ZPP level( 10. 12 μmol/L vs 12. 87 μmol/L)( P = 0. 017 ). The subjects with B allele has larger head circumference than only with b allele(51. 19 cm vs 50. 75 cm)(P = 0. 028 ). Conclusions It was suggested that the ALAD gene polymorphism modified the relationship between blood lead and ZPP and the VDR gene variants influenced the skull development in children living under lead polluted environment. The polymorphism of ALAD and VDR genes might serve as the molecular inherited factors modifing the susceptibility of lead poisoning. |
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