我国原发性开角型青光眼危险因素的病例对照研究

汪宁; 彭智培; 范宝剑; 刘瑶; 董晓梅; 梁旭辉; 栾洁

Abstract

汪宁,彭智培,范宝剑,刘瑶,董晓梅,梁旭辉,栾洁.我国原发性开角型青光眼危险因素的病例对照研究[J].Chinese journal of Epidemiology,2002,23(4):293-296

我国原发性开角型青光眼危险因素的病例对照研究

Case control study on the risk factors of primary open angle glaucoma in China

Received:November 13, 2001 Revised:September 12, 2012

DOI：

KeyWord: 青光眼,开角型流行病学,分子危险因素 TIGR基因

English Key Word: Glaucoma open angle Epidemiology molecular Risk factor TIGR gene

FundProject:日本文部省国际学术研究癌症特别研究经费资助项目(08042015)

Author Name	Affiliation
Wang Ning	Department of Epidemiology & Biostatistics, School of Public Health, Southeast University, Nanjing 210009, China
Peng Zhipei	香港中文大学眼科与视觉科学系
Fan Baojian	Department of Epidemiology & Biostatistics, School of Public Health, Southeast University, Nanjing 210009, China
Liu Yao	东南大学附属中大医院眼科, 南京 210009
Dong Xiaomei	Department of Epidemiology & Biostatistics, School of Public Health, Southeast University, Nanjing 210009, China
Liang Xuhui	香港中文大学眼科与视觉科学系
Luan Jie	东南大学附属中大医院眼科, 南京 210009

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Abstract:

目的　探讨原发性开角型青光眼 (POAG)发病的危险因素。方法　调查两组不同类型的人群资料 ,采用logistic回归分析法探索POAG的危险因素。第一组资料由 1995～ 20 00年的 107例POAG住院患者组成病例组 ,由同期住院的 149例非POAG患者组成对照组。第二组资料由 20 00年 3～ 12月就诊的 40例POAG患者作为病例组 ,由同期就诊的 120例非POAG患者组成对照组。前者采用成组病例对照研究设计 ,后者采用 1∶3匹配病例对照研究设计。对年龄、性别、家族史、糖尿病、高血压、眼压、心血管病、吸烟、饮酒和TIGR基因突变等因素与POAG发病危险性的关系进行研究。结果　单因素分析提示年龄、家族史、高血压、眼压、心血管病、吸烟、饮酒和TIGR基因突变(T353I)等因素与POAG发病有关。logistic回归分析进一步表明 :眼压、家族史、高血压、吸烟、饮酒和TIGR基因突变 (T353I)与POAG关系密切。结论　国人POAG发病的最主要危险因素是眼压 ,其次是家族史、高血压、吸烟和TIGR基因突变 (T353I) ,而饮酒则是POAG的保护因素

English Abstract:

Objective The purpose of this study is to comprehensively explore the risk factors of primary open angle glaucoma (POAG) in China. Methods Two groups of data based on distinct resources were analyzed to explore the risk factors of POAG. One group of data was based on hospital records between 1995 and 2000 which composed of 107 patients with POAG and 149 controls without POAG. The other group of data was based on 40 patients with POAG and 120 matched controls without POAG. The former was designed by non matched case control study, the latter was done by 1∶3 matched case control study. The relationships between POAG and the factors such as age, sex, family history, diabetes, hypertension, intraocular pressure (IOP), cardiovascular diseases, smoking, drinking and mutation of TIGR gene were studied by logistic regression analysis. Results The simple factor analysis showed that the risk of POAG was related to age, family history, hypertension, IOP, cardiovascular diseases, smoking, drinking and the mutation of TIGR gene(T353I). However, logistic regression analysis confirmed that POAG mainly related to IOP, family history, hypertension, smoking, alcohol intake and the mutation of TIGR gene. Conclusion The most important risk factor of POAG was IOP. Family history, hypertension, smoking and the mutation of TIGR gene were also important risk factors of POAG. However, alcohol intake was a protective factor for POAG.

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