银屑病患者的环境因素与HLA-DQA<sub>1</sub>等位基因关联研究

魏生才; 高敏; 张学军; 杨森

Abstract

魏生才,高敏,张学军,杨森.银屑病患者的环境因素与HLA-DQA₁等位基因关联研究[J].Chinese journal of Epidemiology,2002,23(6):445-448

银屑病患者的环境因素与HLA-DQA₁等位基因关联研究

Study of the association between HLA-DQA₁ alleles and environmental factors in psoriasis

Received:November 10, 2001

DOI：

KeyWord: 银屑病|环境因素|HLADQA₁等位基因

English Key Word: Psoriasis|Environmental factor|HLA-DQA₁ alleles

FundProject:国家“863”研究项目资助 (Z19010404)

Author Name	Affiliation	E-mail
WEI Shengcai	Institute of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China
GAO Min	Institute of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China
ZHANG Xuejun	Institute of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China	ayzxj@mail.hf.ah.cn
YANG Sen	Institute of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China

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Abstract:

目的研究Ⅰ型银屑病环境因素与HLA-DQA₁ 等位基因之间的交互作用。方法采用病例对照研究方法,调查了144例Ⅰ型银屑病患者和 273名健康人的环境因素; 用序列特异性引物PCR(PCR-SSP)方法检测HLA DQA₁ 等位基因,对Ⅰ型银屑病的环境因素与HLA DQA₁ 等位基因间交互作用进行了研究。结果 (1)HLA-DQA₁ *0104和DQA₁ *0201与Ⅰ型银屑病患者存在正相关性 (P_c<0.002); HLA-DQA₁ *0501与Ⅰ型银屑病患者存在负相关 (P_c<0.0005)。 (2)HLA-DQA₁ *0104等位基因与受潮 (P=0.0238,OR=5.29)存在交互作用。 (3)HLA-DQA₁ *0201等位基因与10个环境因素无交互作用。 (4)HLA-DQA₁ *0501等位基因与受潮 (P=0.0024,OR=7.50)、食鱼虾 (P=0.0004,OR=12.92)、药物 (P =0.0433,OR =9.43)和接种疫苗 (P=0.0433,OR =9.43)存在交互作用。结论 (1)HLA DQA₁ *0104和DQA₁ *0201可能是Ⅰ型银屑病的易感基因或与易感基因相连锁; HLA DQA₁ *0501等位基因可能具有阻止汉族人发生Ⅰ型银屑病的作用。 (2 )HLA DQA₁ *0104和DQA₁ *0501等位基因能增加环境危险因素发生Ⅰ型银屑病的危险性。

English Abstract:

Objective To study of the HLA-DQA₁ alleles and environment interaction in type I psoriasis.Methods Using case-control study, 144 type Ⅰ psoriatics and 273 healthy people were investigated.The HLA-DQA₁ alleles were examined by PCR-SSP.Results (1)HLA-DQA₁ ＊0104 and DQA₁ ＊0201 alleles were positively associated with type Ⅰ psoriasis (P_c <0.002); HLA-DQA₁ ＊0501 allele was negatively associated with type Ⅰ psoriasis (P_c <0.0005).(2)The HLA-DQA₁ ＊0104 allele and moisture was interaction in type Ⅰ psoriasis (P = 0.0238, OR =5.29).(3) There were no interactions between the HLA-DQA₁ ＊0201 allele and 10 environmental factors in type Ⅰ psoriasis.(4) The HLA-DQA₁ ＊ 0501 allele, moisture (P = 0.0024, OR = 7.50), eating fish and shrimp (P =0.0004, OR =12.92), drugs (P =0.0433, OR =9.43)or vaccination (P =0.0433, OR =9.43)were interacted in type Ⅰ psoriasis.Conclusions (1)HLA-DQA₁ ＊0104 and DQA1 ＊0201 alleles might be the susceptible genes or it may have close linkage with the susceptible gene.HLA-DQA₁ ＊0501 allele had protective effect against the develo pment of type Ⅰ psoriasis.(2) The HLA-DQA₁ ＊0104 and DQA₁ ＊ 0501 alleles increased risk possibility of environmental factors in type Ⅰ psoriasis.

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