| 魏生才,高敏,张学军,杨森.银屑病患者的环境因素与HLA-DQA1等位基因关联研究[J].Chinese journal of Epidemiology,2002,23(6):445-448 |
| 银屑病患者的环境因素与HLA-DQA1等位基因关联研究 |
| Study of the association between HLA-DQA1 alleles and environmental factors in psoriasis |
| Received:November 10, 2001 |
| DOI： |
| KeyWord: 银屑病|环境因素|HLADQA1等位基因 |
| English Key Word: Psoriasis|Environmental factor|HLA-DQA1 alleles |
| FundProject:国家“863”研究项目资助 (Z19010404) |
| Author Name | Affiliation | E-mail | | WEI Shengcai | Institute of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China | | | GAO Min | Institute of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China | | | ZHANG Xuejun | Institute of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China | ayzxj@mail.hf.ah.cn | | YANG Sen | Institute of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China | |
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| Abstract: |
| 目的 研究Ⅰ型银屑病环境因素与HLA-DQA1 等位基因之间的交互作用。方法 采用病例对照研究方法,调查了144例Ⅰ型银屑病患者和 273名健康人的环境因素; 用序列特异性引物PCR(PCR-SSP)方法检测HLA DQA1 等位基因,对Ⅰ型银屑病的环境因素与HLA DQA1 等位基因间交互作用进行了研究。结果 (1)HLA-DQA1 *0104和DQA1 *0201与Ⅰ型银屑病患者存在正相关性 (Pc<0.002); HLA-DQA1 *0501与Ⅰ型银屑病患者存在负相关 (Pc<0.0005)。 (2)HLA-DQA1 *0104等位基因与受潮 (P=0.0238,OR=5.29)存在交互作用。 (3)HLA-DQA1 *0201等位基因与10个环境因素无交互作用。 (4)HLA-DQA1 *0501等位基因与受潮 (P=0.0024,OR=7.50)、食鱼虾 (P=0.0004,OR=12.92)、药物 (P =0.0433,OR =9.43)和接种疫苗 (P=0.0433,OR =9.43)存在交互作用。结论 (1)HLA DQA1 *0104和DQA1 *0201可能是Ⅰ型银屑病的易感基因或与易感基因相连锁; HLA DQA1 *0501等位基因可能具有阻止汉族人发生Ⅰ型银屑病的作用。 (2 )HLA DQA1 *0104和DQA1 *0501等位基因能增加环境危险因素发生Ⅰ型银屑病的危险性。 |
| English Abstract: |
| Objective To study of the HLA-DQA1 alleles and environment interaction in type I psoriasis.Methods Using case-control study, 144 type Ⅰ psoriatics and 273 healthy people were investigated.The HLA-DQA1 alleles were examined by PCR-SSP.Results (1)HLA-DQA1 ＊0104 and DQA1 ＊0201 alleles were positively associated with type Ⅰ psoriasis (Pc <0.002); HLA-DQA1 ＊0501 allele was negatively associated with type Ⅰ psoriasis (Pc <0.0005).(2)The HLA-DQA1 ＊0104 allele and moisture was interaction in type Ⅰ psoriasis (P = 0.0238, OR =5.29).(3) There were no interactions between the HLA-DQA1 ＊0201 allele and 10 environmental factors in type Ⅰ psoriasis.(4) The HLA-DQA1 ＊ 0501 allele, moisture (P = 0.0024, OR = 7.50), eating fish and shrimp (P =0.0004, OR =12.92), drugs (P =0.0433, OR =9.43)or vaccination (P =0.0433, OR =9.43)were interacted in type Ⅰ psoriasis.Conclusions (1)HLA-DQA1 ＊0104 and DQA1 ＊0201 alleles might be the susceptible genes or it may have close linkage with the susceptible gene.HLA-DQA1 ＊0501 allele had protective effect against the develo pment of type Ⅰ psoriasis.(2) The HLA-DQA1 ＊0104 and DQA1 ＊ 0501 alleles increased risk possibility of environmental factors in type Ⅰ psoriasis. |
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