| 吴泰相,刘关键,李平.碘盐预防碘缺乏病随机对照试验的系统评价[J].Chinese journal of Epidemiology,2002,23(6):461-465 |
| 碘盐预防碘缺乏病随机对照试验的系统评价 |
| Systematic review of randomised controlled trial of iodised salt for preventing iodine deficiency disorders |
| Received:December 25, 2001 |
| DOI： |
| KeyWord: 碘缺乏病|碘盐|Cochrane系统评价 |
| English Key Word: Iodine deficiency disorders|Iodised salt|Co chrane systematic review |
FundProject:1.中华医学基金会 (CMB);
2.中国循证医学中心资助项目 |
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| Abstract: |
| 目的 评价碘盐预防碘缺乏病的效果。方法 采用Cochrane系统评价的方法。结果 全世界约 500篇相关文献中, 4项研究为随机对照试验, 符合纳入标准。按照年龄、干预措施和对照措施的不同进行亚组分析, 8～12岁儿童组使用分发碘盐和市场碘盐加碘油胶囊均能有效降低甲状腺肿患病率 (甲肿率), 接近 5%控制线,并明显优于市场碘盐 (OR =0.10,95%CI:0.02～0.17); 市场碘盐虽能使甲肿率下降,但仍不能达到甲肿率控制线 (14.7% )。使用市场碘盐时, 儿童尿碘日排量在不同地区有不同结果,中国的研究结果尿碘水平随市场碘盐浓度的变化而变化,一般能达到 100μg/L以上; 德国和印度尼西亚的研究结果均不能达到碘缺乏病控制线。孕妇组使用市场碘盐预防碘营养不足基本有效,但仍应注意有相当部分孕妇达不到碘营养标准。结论 严格控制质量的碘盐和市场碘盐加碘油制剂能有效消除碘缺乏病 ;但对于市场碘盐消除碘缺乏病,尤其是消除儿童的碘缺乏病的效果评价, 尚需更充分的证据。 |
| English Abstract: |
| Objective To assess the effect of iodised salt for preventing iodine deficiency disorders. Method?? Cochrane systematic review. Results ?? Four randomised controlled trials were included. Subgroup analysis performed lay on different ages, interventions and controls. Prevalence of goitre was reduced close to 5% when using distributed iodised salt and market iodised salt plus iodine oil capsule which showed more effective than using market iodised salt alone ( OR = 0.10, 95% CI : 0.02- 0.17). The latter’s prevalence of goitre was 14.7%. When using market iodised salt, the iodine urea excretion level showed different results in children group in different countries. Basically, the market iodised salt for preventing iodine deficiency of preg nancy women were effective, but a part of them did not achieve to the ideal status of iodine nutrition. Conclusions?? The needs to be strictly controlled quality of iodised salt and market iodised salt plus iodised oil capsule thus can effectively reduce the prevalence of iodine deficiency disorders. However there was not enough evidence to support that market iodised salt can effectively eliminate these disor ders, particularly in children. More eligibility trials are needed for providing more evidences. |
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