流行性乙型脑炎灭活疫苗与减毒活疫苗相结合的免疫策略研究

马福宝; 郑理; 毕诚; 陶红; 周永林; 张晋琳; 汤奋扬; 解平; 郑春早; 姜仁杰; 澎维斌

Abstract

马福宝,郑理,毕诚,陶红,周永林,张晋琳,汤奋扬,解平,郑春早,姜仁杰,澎维斌.流行性乙型脑炎灭活疫苗与减毒活疫苗相结合的免疫策略研究[J].Chinese journal of Epidemiology,2003,24(2):113-115

流行性乙型脑炎灭活疫苗与减毒活疫苗相结合的免疫策略研究

Study on the strategy of Japanese encephalitis immunization using live attenuated vaccine combined with inactivated vaccine

Received:June 19, 2002

DOI：

KeyWord: 脑炎,日本2型灭活疫苗减毒活疫苗免疫效果

English Key Word: Encephalitis Japanese B Inactivated vaccine Live attenuated vaccine Immune effect

FundProject:江苏省“135”工程资助项目 (JSE17)

Author Name	Affiliation
MA Fu bao	Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China
ZHENG Li	Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China
BI Cheng	Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China
TAO Hong	Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China
ZHOU Yong lin	Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China
ZHANG Jin lin	Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China
TANG Fen yang	Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China
XIE Ping	兴化市卫生防疫站防疫科
ZHENG Chun zao	盐城市卫生防疫站防疫科
PENG Wei bin	盐城市卫生防疫站防疫科
JIANG Ren jie	泰州市卫生防疫站防疫科

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Abstract:

目的为合理利用流行性乙型脑炎(乙脑)灭活疫苗和减毒活疫苗各自的优点,降低预防接种反应的发生率,提高免疫学效果,开展了乙脑灭活疫苗与减毒活疫苗相结合的免疫策略研究。方法观察比较两种疫苗单一使用与联合使用的免疫学效果及安全性。结果联合使用组在疫苗接种后24h的全身中强以上发热反应发生率为0.73%,局部红晕反应为1.46%,而单一使用灭活疫苗组的发热反应发生率为2.8%。不同观察组疫苗接种后中和抗体几何平均滴度由免疫前的1∶1.05～1∶3.35上升至1∶47.34～1∶101.30,联合使用组的中和抗体阳转率为97.67%,明显高于单一使用灭活疫苗组86.27%的阳转率(x²=3.89,P<0.05),但与单一使用减毒活疫苗组93.75%的阳转率差异无显著性(x²=0.74,P<0.05)。结论研究表明对婴幼儿使用乙脑灭活疫苗基础免疫、减毒活疫苗加强免疫有很好的免疫学效果及安全性,也是切实可行和比较理想的免疫策略

English Abstract:

Objective Using the advantages of Japanese encephalitis live attenuated and inactivated vaccine, to reduce the rate of immunization reaction and to increase the effect, we conducted a study on the strategy of immunization in Japanese encephalitis using live attenuated vaccine combined with inactivated vaccine. Methods Observing the safety and immune effects of different groups. Results Data on side effect showed that the rate of moderate and severe systematic reactions of the group who were inoculated with combined vaccine was 0.73 %, with local reaction 1.46% while the combined rate of moderate and severe systematic reaction of the group who were inoculated with inactivated vaccine was 2.8 %. Under the detection of serum neutralizing antibody, the GMT rose from 1∶1.05 1∶3.35 before vaccination to 1∶47.34 1∶101.30 after vaccination in the different groups. Neutralizing antibody was detected in 97.67 % of the combined group. There was a significant difference by comparing neutralizing antibody seroconversion rate of the combined group with the inactivated group(x²=3.89, P<0.05), but no significant difference with attenuated group(x²=0.74, P<0.05). Conclusion Results showed that in children who previously had been immunized with two doses of inactivated vaccine, the booster administration of live attenuated vaccine was both effective and safe.

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