参芪扶正注射液拮抗肺癌化疗毒副反应的成本分析

柏长青; 倪殿涛; 李宁秀; 刘关健; 董碧蓉

Abstract

柏长青,倪殿涛,李宁秀,刘关健,董碧蓉.参芪扶正注射液拮抗肺癌化疗毒副反应的成本分析[J].Chinese journal of Epidemiology,2003,24(2):130-134

参芪扶正注射液拮抗肺癌化疗毒副反应的成本分析

Cost analysis of Shenqi Fuzheng injection on reducing adverse effects during chemotherapy

Received:February 05, 2002

DOI：

KeyWord: 参芪扶正注射液肺肿瘤化学疗法费用效益分析交叉试验

English Key Word: Shenqi Fuzheng injection Lung neoplasms Chemotherapy Cost effectiveness analysis Cross over design

FundProject:国际临床流行病学网络 (INCLEN)资助项目

Author Name	Affiliation
BAI Chang qing	Department of Pulmonary Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
NI Dian tao	Department of Pulmonary Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
LI Ning xiu	四川大学公共卫生学院社会医学教研室
LIU Guan jian	医学统计学教研室
DONG Bi rong	四川大学华西医院老年病科

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Abstract:

目的从经济学角度评价传统中药党参、黄芪提取物——参芪扶正注射液在肺癌患者化疗中的应用价值。方法采用随机交叉试验设计,每个患者完成2个化疗周期,试验周期使用参芪扶正注射液,对照周期不使用参芪扶正注射液。观察患者化疗毒副反应和化疗期间的生命质量,比较患者用于拮抗化疗毒副反应的直接成本并进行成本效果分析。结果130例纳入试验,完成2个周期化疗123例。加入参芪扶正注射液后患者化疗期间发生Ⅲ级以上严重白细胞减少、血小板减少和呕吐反应人数明显减少,生命质量的多项维度明显改善,成本效果分析明显优于对照未使用参芪扶正注射液的对照周期。结论参芪扶正注射液能够明显降低化疗期间常见毒副反应的发生率,改善患者化疗期间的生命质量,具有一定的成本效果优势

English Abstract:

Objective The goals of this work was to analyse the cost of Shenqi Fuzheng injection an extraction of a Chinese traditional herbs on reducing adverse effects in lung cancer patients during chemotherapy. Methods In a randomized cross over trial, each patient completed two identical cisplatin based chemotherapy cycles, one with Shenqi Fuzheng injection, another without Shenqi Fuzheng injection. Adverse effects and change scores of quality of life (QOL) during chemotherapy were compared in tow cycles. The direct cost dealed with adverse effect and cost effectiveness analysis were taken. Results One hundred and thirty were enrolled with 123 of whom were evaluable. The patient characteristics were well balanced between the two groups. The chemotherapy cycles with Shenqi Fuzheng injection spent 220.5 more Chinese yuan, but the adverse effect of leukopenia, thrombocytopenia and vomiting were slight different and the change of score of several QOL domains showed singnigicant better as comparerd to those in another cycle. Conclusion Shenqi Fuzheng injection could reduce the severity of toxicity related to chemotherapy and improve the QOL of patients and had some benefits in terms of cost effectiveness.

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