| 吕筠,李立明,曹卫华,詹思延,胡永华.苯那普利致咳嗽不良反应的监测及其危险因素研究[J].Chinese journal of Epidemiology,2003,24(5):401-404,405 |
| 苯那普利致咳嗽不良反应的监测及其危险因素研究 |
| Postmarketing surveillance of benazepri-l related cough and related risk factors analysis on hypertensives |
| Received:November 24, 2002 |
| DOI： |
| KeyWord: 血管紧张素转换酶抑制剂 咳嗽 饮酒 吸烟 肾功能衰竭 |
| English Key Word: Angiotensin converting enzyme inhibitor Cough Alcohol drinking Smoking Kidney failure |
| FundProject:国家“九五”科技攻关基金资助项目 (969060205 ) |
| Author Name | Affiliation | | LU Jun | Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100083,China | | LI Li-ming | 北京大学医学部公共卫生学院流行病与卫生统计学系 100083 | | CAO Wei-hua | Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100083,China | | ZHAN Si-yan | Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100083,China | | HU Yong-hua | Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100083,China |
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| Abstract: |
| 目的研究苯那普利相关咳嗽不良反应的危险因素。方法对1831例高血压患者进行连续3年的用药观察,随访记录咳嗽不良反应发生情况,并嵌套病例对照研究,进行危险因素分析。结果服用苯那普利后半年内,咳嗽不良反应的发生率女性为18.35%,男性为12.11%。logistic回归分析显示,女性(OR=2.193,95%CI:1.500～3.206)、肾功能失代偿的女性(OR=3.432,95%CI:1.954～6.028)、女性65岁以上(OR=1.672,95%CI:1.040～2.688)、男性饮白酒100g/日以上(OR=2.478,95%CI:1.148～5.347)发生咳嗽不良反应的危险性增加。结论女性、老年、饮白酒、肾功能失代偿是苯那普利致咳嗽不良反应发生的可能危险因素,但不是主要的危险因素。 |
| English Abstract: |
| Objective To investigate the risk factors of benazepril related cough.Methods Case-control study nested in a community-based postmarketing surveillance was carried out One thousand eight hundred and thirty-one hypertensive patients screened from a Chinese community were recruited to take benazepril for 3 years.Demographic characteristics and behavior risks were investigated and the level of uric acid and creatinine were tested at baseline.Episodes of benazepril related cough during follow period were recorded.Results Within half a year of administration,the incidence rates of cough were as high as 18.35% in women and 12.11% in men.Incidence decreased significantly when time went by.Two years later of administration,first occurrences of cough were still seen.Based on logistic regression analysis,women were more likely to develop cough (OR= 2.193,95% CI:1.500-3.206).The association between decompensated kidney function and cough occurrence was only detected in women (OR =3.432,95% CI:1.954-6.028).Women aged 65 or more had 1.672 (95% CI:1.040-2.688) times risk than women aged 35 to 64 years.In men,the OR of developing cough was 1.689( 95%CI 0.976-2.924) for daily drinking alcohol less than 100 g but increased to 2.478( 95%CI:1.148-5.347) when drinking 100 g or more,but not the determinant ones.Conclusion Women,older age, drinking alcohol and decompensated kidne function were the possible risk factors for benazepril related cough, but not the determinant ones. |
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