| 陈鹏,江艳芬,程康.中国原发性高血压患者血管紧张素原M235T多态性Meta分析[J].Chinese journal of Epidemiology,2003,24(8):711-714 |
| 中国原发性高血压患者血管紧张素原M235T多态性Meta分析 |
| Meta-analysis on the association of AGT M235T polymorphism and essential hypertension in Chinesepopulation |
| Received:June 20, 2002 |
| DOI： |
| KeyWord: 高血压 血管紧张素原 多态现象 Meta分析 |
| English Key Word: ypertension Angiotensinogen Polymorphism Meta-analysis |
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| Abstract: |
| 目的 对血管紧张素原 (AGT)基因第二外显子M235T多态性与原发性高血压的关联性进行Meta分析。方法 以原发性高血压组和健康对照组基因型分布的OR值为统计量。全面检索相关文献,剔除不符合要求的文献,应用REVMAN 4.1软件对各研究结果进行一致性检验和数据合并,并评估发表偏倚的影响。结果 10篇文献无明显异质性。共包括原发性高血压组患者 853例,健康对照组 835名,合并TT/ (MT +MM )OR =1.76,95 %CI :1.44～2.16,P<0.00001,T/MOR =1.54,95%CI:1.31～ 1.81,P<0.00001。结论 中国人(汉族为主 )AGTM2 35T多态性的T等位基因和TT基因型与原发性高血压危险性增加有关联。 |
| English Abstract: |
| Objective To study on the association of M235T polymorphism of the angiotensinogen gene extron 2 (AGTM 235T)and essential hyper tension (EH)in Chinese population by means of Meta-analysis.Methods Odds ratios (OR) of AGTM 235T geno type distributions in EH patients against healthy controls were analyzed.All the relevant studies were identified, poor-qualified studies eliminated,and the risk of publication bias excluded.The Meta-analysis software,REVMAN 4.1,was applied for investigating he terogeneity among individual studies and summarizing the effects across studies.Results A to tal of 853 cases and 835 controls from 10 studies were included.No heterogeneity among the studies was noticed.The frequencies of the AG TTT,MT and MM genoty pes were 65%,30%,and 4.9% in cases and 50.6%,41.8% and 7.5% in controls respectively.The frequencies of the AG T T allele were 80% in cases and 72% in contro ls.T he pooled OR (with 95% CI)of TTvs MT +MM was 1.76(1.44-2.16)(P<0.00001)with vs M 1.54(1.31-1.81).The pooled OR of MM vs M T+TT was 0.67(0.45-1.00)(P=0.05).Conclusion In Chinese population (mainly the Hans),TT genotype might be associated with the increased risk of EH while MM genotype be associated with low risk of EH. |
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