| 史宝林,张勇,武艳华,张杰.脑梗死的遗传流行病学研究[J].Chinese journal of Epidemiology,2003,24(8):719-721 |
| 脑梗死的遗传流行病学研究 |
| A study on genetic epidemiology of cerebral infarction |
| Received:October 13, 2002 |
| DOI： |
| KeyWord: 脑梗死 遗传流行病学 |
| English Key Word: Cerebr al infarction Genetic epidemiology |
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| Abstract: |
| 目的 探讨脑梗死的遗传方式以及遗传因素在脑梗死发病中的作用。方法 采用遗传流行病学配对病例对照研究方法,对 112对脑梗死先证者家系和对照家系的脑梗死发病情况进行研究,使用Li Mantel Gart法及Falconer法估算脑梗死的分离比和遗传度。结果 病例组一、二级亲属脑梗死患病率明显高于对照组亲属 (P <0.05 ) ;分离比为 0.1437(0.1130～ 0.1744 ),显著低于0.25,不符合单基因遗传性疾病的特征 ;遗传度估算结果,患者一、二级亲属遗传度分别为 47.84 %±4.55 %和 40.95 %± 13.05 %,其中男性高于女性。结论 脑梗死属多基因遗传方式,遗传因素对其发病有一定的作用。 |
| English Abstract: |
| Objective To explore the genetic model of cerebral infarction and to examine the relationship between cerebral infarction and genetic factor.Methods A matched case-control study including 112 pairs pedigrees was carried out. Using the L-i M ante-l Gart method and the Falconer method to estimate the segreg at ionratio and the heritability of cerebral infarction.Results The prevalence rate of the firs-t degree and the second-degree relatives in cases was significantly higher than that in controls.The seg regation ratio was 0.1437 (0.1130- 0.1744),significantly lower than 0.25, which showed that cerebral infarction did not possess the characteristics of monogenetic model. The results showed that the heritability of the firs-t degree and the second-degree relatives were 47.84% and 40.95% higher in males than in females. Conclusion Cerebral infarction was a poly genetic disease, and the genetic factors played an important role in the occurrence of cerebral infarction, especially in males |
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