上海市大气污染与居民每日死亡关系的病例交叉研究

阚海东; 陈秉衡; 贾健

Abstract

阚海东,陈秉衡,贾健.上海市大气污染与居民每日死亡关系的病例交叉研究[J].Chinese journal of Epidemiology,2003,24(10):863-867

上海市大气污染与居民每日死亡关系的病例交叉研究

A case-crossover study of ambient air pollution and daily mortality in Shanghai

Received:October 21, 2002

DOI：

KeyWord: 大气污染病例交叉设计死亡率

English Key Word: Air pollution Case-crossover Mortality

FundProject:

Author Name	Affiliation
KAN Hai-dong	Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China
CHEN Bing-heng	Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China
JIA Jian	上海市闸北区疾病预防控制中心

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Abstract:

目的以病例交叉的研究方法,估计大气污染急性暴露对上海市居民每日死亡的影响,并探讨该设计用于大气污染急性健康效应研究的可行性。方法采用病例交叉设计的方法分析上海市2000年6月1日至2001年12月31日大气污染与居民每日总死亡和分疾病别死亡的关系,同时比较双向对照设计和单向回顾性对照设计研究结果的差异。结论采用不同的对照选择方案,病例交叉设计的研究结果变化较大;采用双向1∶6的对照设计,大气可吸入颗粒物(PM₁₀)、二氧化硫(SO₂)、二氧化氮(NO₂)48h平均浓度每增加10μgm³,上海市城区居民总死亡发生的相对危险度分别为1.003(95%CI:1.001～1.005)、1.016(95%CI:1.011～1.021)、1.020(95%CI:1.012～1.027)。结论上海市城区目前的PM₁₀、SO₂、NO₂水平对居民死亡确有影响;病例交叉设计是一种研究大气污染急性健康效应的有效工具

English Abstract:

Objective Using case-crossover design to estimate the acute effect of ambient air pollution on daily mortality in Shanghai, and to ex plore the applicability of if in studying the acute health effects of air pollution.Methods Case-crosso ver technique was used to evaluate the relatio nship between air pollution and daily mortality from June 2000 to December 2001 in Shanghai.The results of the bidirectional control sampling approach were compared with unidirectional approach.Results　The validity of relative risks in case-crossover studies varied g reatly depending on the strategy used in control sampling.When a bi-directio nal six control sampling approach was used an increase of relative risk of non-accident mo rtality on each 10 μg m³ over a 48-hr moving average of PM10, SO2 and NO2 correspo nds to 1.003(95 %CI :1.001-1.005), 1.016(95 %CI :1.011-1.021), and 1.020(95%CI :1.012-1.027) respectively was seen.Conclusion　The results reinforced the deleterious role of current air pollution level on human health in Shanghai, and provided info rmation on the applicability of case-cro ssover design in studying the acute health effects of air pollution.

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