四川省恶性淋巴瘤发病与环境因素的病例对照研究

徐才刚; 郑素萍; 黄杰; 吴谨绪

Abstract

徐才刚,郑素萍,黄杰,吴谨绪.四川省恶性淋巴瘤发病与环境因素的病例对照研究[J].Chinese journal of Epidemiology,2003,24(10):875-878

四川省恶性淋巴瘤发病与环境因素的病例对照研究

A case-control study f or assessing the relation between the incidence of malignant lymphomas andenvironmental factors in Sichuan province

Received:October 21, 2002

DOI：

KeyWord: 淋巴瘤环境接触病例对照研究

English Key Word: Lymphoma Enviro nmental ex posure Case-co ntrol study

FundProject:国际临床流行病学网(INCLEN )和美国洛氏基金资助项目

Author Name	Affiliation
XU Cai-gang	Department of Clinical Epidemiology and Hematology, Huaxi Hospital, Sichuan University, Chengdu 610041, China
ZHENG Su-ping	Department of Clinical Epidemiology and Hematology, Huaxi Hospital, Sichuan University, Chengdu 610041, China
HUANG Jie	Department of Clinical Epidemiology and Hematology, Huaxi Hospital, Sichuan University, Chengdu 610041, China
WU Jin-xu	Department of Clinical Epidemiology and Hematology, Huaxi Hospital, Sichuan University, Chengdu 610041, China

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Abstract:

目的探讨职业、环境因素、某些药物、社会经济及生活行为因素与淋巴瘤发病的相关性。方法采用1∶2配对病例对照研究,恶性淋巴瘤150例(病例组),非肿瘤病例300例(对照组),结果用logistic回归分析。结果(1)接触有机溶剂,如苯[调整OR(aOR)=2.78,P=0.001]、香蕉水(aOR=2.28,P=0.043)、油漆(aOR=1.96,P=0.023)和接触农药,包括有机磷类(aOR=1.98,P=0.034)、菊酯类(aOR=2.57,P=0.013)以及有机氮类(aOR=2.55,P=0.003)会增加淋巴瘤发病的危险性。(2)经常使用一些药物,如阿斯匹林(aOR=2.36,P=0.005)会使淋巴瘤发病的危险性增加。(3)饲养宠物狗(aOR=1.76,P=0.034)与淋巴瘤发病的危险性增加有一定关系。(4)定期接受小剂量X线照射(aOR=0.49,P=0.015)、经常患感冒(aOR=0.67,P=0.024)则可能降低淋巴瘤发病的危险性。(5)职业(P>0.05)、吸烟(OR=1.01,P=0.897)、戒烟(OR=1.17,P=0.073)、饮酒(aOR=1.26,P=0.414)、染发(OR=1.06,P=0.850)、烫发(OR=1.26,P=0.438)、经济状况(OR=1.00,P=1.000)和内向性格(OR=1.26,P=0.266)与淋巴瘤发病无明显相关性。结论接触有机溶剂和经常服用某些药物(阿斯匹林)可增加恶性淋巴瘤发病的危险性。

English Abstract:

Objective To ev aluate the relationships of malignant lymphoma (ML) and ex posure factors, including environmental, drug using, socioeconomic level and life style etc.Methods　(1)Hospitalbased case-contro l study with 1∶2 matching was used;(2)150 cases of M L and 300 controls were resulted; (3) logistic reg ression was used.Results (1)Adjust odds ratios (aOR) regarding contact to organic solvents were :benzene aOR =2.78, P =0.001 ;banana oil aOR =2.28, P =0.043 ;paint aOR =1.96,P =0.023;(2) aOR on pesticides contact :organic phosphorus aOR =1.98, P =0.034;chry santhester aOR =2.57, P =0.013 ;o rganic nitride aOR =2.55, P =0.003 ;(3) aOR of using aspirin was 2.36,P =0.005 ;(4)do g-raising :aOR =1.76, P =0.034 ;(5)the aORs of interval-term ex posure to small dosage X-ray was 0.49, P =0.015, and frequently catching cold was 0.67, P =0.024;(6)the P-value of different occupations was more than 0.05 ;cigarette smoking OR =1.01, P =0.897 ;giving up smoking OR =1.17, P =0.073;alcohol-drinking aOR =1.01, P =0.414 ;hair-dy es OR =1.06, P =0.850;hairperms OR =1.26, P =0.438;socioeconomic level OR =1.00, P =1.000 and with introversive character OR =1.26, P =0.266.Conclusions　(1)Factors that mig ht increase the risk of suffering from malig nant lymphomas would include direct contact to org anic solvents and some pesticides (organic phosphorus,chrysanthester and organic nitride), intake of aspirin, as well as do g-raising.(2)Regular ex posure to small dosage X- ray and frequently ca tching cold seemed to decrease the risk of suffering from ML.(3)Occupation, smoking, giving up smoking, alcohol-drinking, hair-dyes, hair-perms, socioeconomic level and introv ersive character showed no significant relations to the risk of suffering from ML in this study.

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