| 徐红.中国2002～2003年度流行性感冒监测分析[J].Chinese journal of Epidemiology,2003,24(11):995-998 |
| 中国2002～2003年度流行性感冒监测分析 |
| Influenza surveillance program in 2002-2003,in China |
| Received:October 08, 2003 |
| DOI： |
| KeyWord: 流行性感冒病毒 亚型 监测 |
| English Key Word: Influenza virus Subtype Surveillance |
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| Abstract: |
| 目的阐明2002年4月至2003年6月国内流行性感冒(流感)流行特点和流感病毒优势株的特性。方法流感病毒分离采用鸡胚和细胞分离;流感病毒亚型鉴定采用血球凝集抑制试验;对流行株的HA基因核酸测序,分析其亲缘关系和抗原变异性。结果2002年4月至2003年6月,全国23个省(市)和自治区共采集流感样患者咽拭子标本共计16135份,经鉴定流感病毒阳性1113株,分离率6.9%。在1113株流感病毒中,A1型66株、A3型544株、B型流感病毒Yamagada98株和Victoria405株,分别占总分离数的5.9%、48.9%、8.8%和36.4%。优势流行株为H3N2和B型Victoria株。A3型流感病毒除主要分离于2002年12月和2003年1月外,在非流行高峰期也有一定数量的分离。而B型Victoria系流感病毒主要集中分离于冬季流行高峰期,其流行株核酸序列分析属B型Victoria系株。A3型毒株血凝素基因的HA1系统树分析表明,其与APanama200799同源,且有某些变异存在。结论虽然感染人群的流感毒株依然是A1、A3和B型交叉出现,但以A型(H3N2)和B型Victoria为优势株。与历年不同,B型Victoria分离比例增加及分布广泛是2002～2003年度的特点。A型(H3N2)流行株有变异迹象值得密切注意。 |
| English Abstract: |
| Objective To study the prevalence of influenza viruses from April 2002 to June 2003. Methods Subtypes were identified by HI test, HA gene was amplified by RT-PCR and the nucleotide sequences of HA gene were analyzed. Results During theperiod of April 2002 to June 2003, a total number of 16 135 throaTswab specimens were collected in 23 provinces, metropolitans and municipalities with 1113 strains identified as influenza viruses positive, by the Chinese National Influenza Center. The rate of isolation was 6.9%. Of the 1113 strains, 66 strains were influenza A-H1N1, 544 strains were influenza A-H3N2 viruses while 98 and 405 strains belonged to B PYamagata and B PVictoria viruses with the rates of isolation on each subtype were 5. 9%, 48. 9%, 8. 8% and 36. 4%, respectively. Majority of influenza A (H3N2) viruses were isolated in the epidemicperiod of December 2002 and January 2003 as well as in the non-epidemicperiod. DifferenTto influenza A-H3N2, mosTof the BPVictoria viruses were isolated in winter. The HA1 gene of B type strains belonged to B PVictoria lineage. Sequence analysis indicated thaTthere were variations in influenza type in this epidemic season. Conclusions Although influenza A subtype H1N1 and H3N2 as well as B type viruses were co-circulating in our country, the influenza A (H3N2) and B PVictoria isolates were found the predominanTstrains in theperiod of this study which were differenTfrom the previous years. The facTthaTthe increase of proportion on B PVictoria and its widespread in many areas suggested there had been a change of epidemiological features caused by influenza viruses in China. ITseemed importanTto pay more attention to the variation of HA gene in influenza A type ( H3N2) strains. |
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