静脉吸毒共用注射器具方式和性行为与丙型肝炎病毒感染关系的研究

周枫; 马泽恩; 胡薇; 冯宗亮; 陈康林; 秦光明; 孙乔; 刘刚; 梁姝; 何益新; 刘石柱; 阮玉华; 邵一鸣

Abstract

周枫,马泽恩,胡薇,冯宗亮,陈康林,秦光明,孙乔,刘刚,梁姝,何益新,刘石柱,阮玉华,邵一鸣.静脉吸毒共用注射器具方式和性行为与丙型肝炎病毒感染关系的研究[J].Chinese journal of Epidemiology,2004,25(4):329-332

静脉吸毒共用注射器具方式和性行为与丙型肝炎病毒感染关系的研究

Study on the relationship between hepatitis C virus infection and sharing injection equipment,sexual behavior among injecting drug users

Received:July 09, 2003

DOI：

KeyWord: 静脉吸毒共用注射器具肝炎病毒,丙型性行为

English Key Word: Injection drug user Sharing injeclion equipment Hepatitis virlls C: Sexua1 behavior

FundProject:国家“十五”科技攻关课题资助项目(2001 BA705B02);国家自然科学基金(30170823)

Author Name	Affiliation
ZHOU Feng	Peking Union Medical College,Union School of Public Health,Beijing 100021, China
MA Ze-en	Peking Union Medical College,Union School of Public Health,Beijing 100021, China
HU Wei	RUAN、Yu-hua. National Cenater for Sexually Transmitted Disease and Acquired ImmuneSyudtome Prevenaiwu and GwuatoL, Chinese Genaer for Disease Control and Prevention Beijing 100050,China
FENG Zong-liang	RUAN、Yu-hua. National Cenater for Sexually Transmitted Disease and Acquired ImmuneSyudtome Prevenaiwu and GwuatoL, Chinese Genaer for Disease Control and Prevention Beijing 100050,China
CHEN Kang-lin	RUAN、Yu-hua. National Cenater for Sexually Transmitted Disease and Acquired ImmuneSyudtome Prevenaiwu and GwuatoL, Chinese Genaer for Disease Control and Prevention Beijing 100050,China
QIN Guang-ming	RUAN、Yu-hua. National Cenater for Sexually Transmitted Disease and Acquired ImmuneSyudtome Prevenaiwu and GwuatoL, Chinese Genaer for Disease Control and Prevention Beijing 100050,China
SUN Qiao	四川省疾病预防控制中心
LIU Gang	四川省疾病预防控制中心
LIANG Shu	四川省疾病预防控制中心
HE Yi-xin	Peking Union Medical College,Union School of Public Health,Beijing 100021, China
LIU Shi-zhu	Peking Union Medical College,Union School of Public Health,Beijing 100021, China
RUAN Yu-hua	中国疾病预防控制中心性病艾滋病预防控制中心
SHAO Yi-ming	中国疾病预防控制中心性病艾滋病预防控制中心

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Abstract:

目的了解四川省凉山州某地区静脉吸毒人群共用注射器具方式及性行为与丙型肝炎病毒(HCV)感染的关系。方法以社区为基础使用标准化问卷调查静脉吸毒人群人口学特征和静脉吸毒共用注射器具方式、性行为情况;通过检测研究对象的HCV抗体确定是否感染HCV。结果在静脉吸毒379人中,静脉吸毒人群HCV感染率为对71.0%(269/379)。单因素分析结果显示近3个月共用针头或注射器和既往感染梅毒在HCV感染方面差异有统计学意义。趋势性检验发现随着共用针头或注射器、共用洗针头或注射器水的频率以及共用注射器具伙伴数的增加HCV的感染率也在增加。多因素分析结果显示,近3个月共用针头或注射器。既往感染梅毒是HCV感染的危险因素,其OR值分别为1.468(95%CI:1.045～2.061)和2.914(95%CI:1.327～6.398)。未见性行为对HCV感染的影响。结论需考虑采用定群血清流行病学研究来进一步阐明静脉吸毒共用注射器具方式及性行为同HCV感染的关系及其联系强度。

English Abstract:

Objective To study hepatitis C virus (HCV) transmission through different modes of sharing injection equipment and sexual behavior among injecting drug users (IDUs) in Liangshan of Sichuan province. Methods A community-based survey was conducted to investigate past and current demographic data,injection equipment sharing patterns and sexual behavior of IDUs. Blood samples were also taken to test for HCV. The survey was conducted between Nov 8 and Nov 29,2002. 379 subjects were screened through outreach recruitment and peer informing. SPSS(11.5) was used for data analysis. Results HCV prevalence was 71.0%(269/379). Needles or syringes sharing in the past three months and past syphilis infection were strongly associaled with HCV transmission after univariate analysis using chi-square test. Trend analysis indicated that HCV infection rate increased along with the increase of needles or syringes sharing,sharing of rinse water and the number of peers sharing the equipments. Data from multivariate logistic regression showed that sharing of needles or syringes and history of syphilis infection were significantly associated with HCV transmission. No significant difference was found between HCV infection and sexual behavior after univariate analysis using chi-square test. ConclusionFurther sero-epidemiological prospective cohort studies should be conducted to clarify the relationship between different modes of sharing injection equipment, sexual behavior and HCV infection.

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