病例父母亲对照研究

易洪刚; 陈峰

Abstract

易洪刚,陈峰.病例父母亲对照研究[J].Chinese journal of Epidemiology,2004,25(5):439-444

病例父母亲对照研究

Case-parental control study

Received:August 11, 2003

DOI：

KeyWord: 流行病学关联基因交互作用传递不平衡检验

English Key Word: Epidemiology Association Gene Interaction Transmission disequilibrum test

FundProject:

Author Name	Affiliation
Yi Hong-gang	Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China
Chen Feng	Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China

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Abstract:

目的: 介绍病例父母亲对照研究的设计及统计分析方法。方法: 以TIVS7-2等位基因与人类神经管缺损关联研究为实例, 采用单体型相对风险（HRR）分析、基因型相对风险（GRR）分析、传递/不平衡检验（TDT）等方法进行统计分析。结果: 采用HRR分析, HRR=1.33（X²=1.4618, P=0.2266; 采用GRR分析, ψ₁=1.26, ₂=0.98(X₂²=3.1809,P=0.2038); 采用TDT其值为1.4516（P=0.2283）。提示TIVS7-2等位基因与神经管缺损有微弱关联, 但HRR经检验差异均无统计学意义。结论: 病例父母亲对照设计使用患者双亲作为对照, 避免了人群分层现象, 可以用来检测与疾病发病相关的基因及评价基因与环境暴露的交互作用。

English Abstract:

Objective: To introduce the methodology on the design and statistical method as well as analysis of published data related to case-parental control study. Methods: Data from a research on association between the human neural tube defects and the T allelic variant TIVS7-2 was analyzed by haplotype relative risk(HRR), genotype relative risk (GRR) and transmission/disequilibrunt test (TDT) methods. Results: Using the HRR method, HRR value was 1.33 (chi-square statistic is 1.4618 with P=0.2266) The Results of the GRR method showed that ψ₁ value was 1.26 and ψ₂ value was 0.98 (chi-square statistic is 3.1809 with 2 df, P=0.2038). The transmission/disequilibrium test showed that TDT was 1.4516 with P= 0.2283. All results suggested that when a weak association of TIVS7-2 allele with neural tube defects was found, there was no evidence showing the statistical difference. Conclusion: The case-parental control design method avoids population stratification when parents used as controls. This method might be used to test the association between genes and disease, as well as to evaluate the gene ennvironmental interaction.

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