| 穆丽娜,丁保国,陈传炜,卫国荣,周学富,王如鸿,蔡琳,张作风,姜庆五,俞顺章.亚甲基四氢叶酸还原酶677基因多态性与胃癌危险度关系病例对照研究[J].Chinese journal of Epidemiology,2004,25(6):495-498 |
| 亚甲基四氢叶酸还原酶677基因多态性与胃癌危险度关系病例对照研究 |
| A case-control study on the relationship between methyl-tetra-hydrofolic acid reductase 677 gene polymorphism and the risk of stomach cancer |
| Received:May 08, 2003 |
| DOI： |
| KeyWord: 胃肿瘤 亚甲基四氢叶酸还原酶 基因多态性 病例对照研究 |
| English Key Word: Stomach neoplasms Methyl-tetra-hydrofolic acid reductase Genetic polymorphism Case-control study |
| FundProject: |
| Author Name | Affiliation | | MU Li-na | School of Public Health,Fudan University,Shanghai 200032,China | | DING Bao-guo | 江苏省泰兴市疾病预防控制中心 | | CHEN Chuan-wei | School of Public Health,Fudan University,Shanghai 200032,China | | WEI Guo-rong | School of Public Health,Fudan University,Shanghai 200032,China | | ZHOU Xue-fu | 江苏省泰兴市疾病预防控制中心 | | WANG-hong | 江苏省泰兴市疾病预防控制中心 | | CAI Lin | 福建医科大学 | | ZHANG Zuo-feng | University of Califomia, Los Angles School of Public Health | | JIANG Qing-wu | School of Public Health,Fudan University,Shanghai 200032,China | | YU Shun-zhang | School of Public Health,Fudan University,Shanghai 200032,China |
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| Abstract: |
| 目的 探讨亚甲基四氢叶酸还原酶(MTHFR)677基因多态性与胃癌危险度的关系。方法 采用以人群为基础的病例对照研究方法,聚合酶链反应-限制性片段长度多态性法用于检测MTHFR677的基因型。结果 胃癌病例组中,MTHFR677 C/C、C/T、T/T三种基因型的频率分别为25.8％、54.6％、19.6％。对照组中三种基因型频率分别为34.5％、50.9％、14.6％。以C/C基因型作为参照基因型,C/T或T/T两种基因型的OR值为1.52(95％CI:1.04～2.23)。胃癌病例组中C和T两种等位基因型频率分别为53.3％和46.7％,对照组中分别为60.0％和40.0％。以C等位基因为参照,T等位基因的OR为1.31(95％CI:1.02～1.69)。此外研究还显示:MTHFR677AnyT基因型可能与吸烟、霉变粮食、大麦粥摄入、盐的过量摄入以及幽门螺杆菌CagA的感染发生交互作用而增加个体患胃癌的危险度。而该基因型与饮酒和饮茶未见明显的交互作用。结论 当个体携带C/T或T/T基因型时,患胃癌的危险度上升;携带AnyT基因型还可与其他环境危险因素发生交互作用,增加个体患胃癌的危险度。 |
| English Abstract: |
| Objective To explore the relationship between methyl-tetra-hydroflic acid (MTHFR) 677 gene polymorphism and the risk of stomach cancer.Methods A population based case-control study was conducted and polymerase chain reaction-restriction fragment length poymorphism (PCR-RFLP) method was used to detect its genotypes.Results Among cases with stomach cancer,the frequency of C/C, C/T, T/T genotype were 25.8%,54.6%,19.6%,compared with controls as 34.5%,50.9%,14.6% respectively.Using C/C genotype as reference,the OR of C/T or T/T genotype was 1.52(95% CI: 1.04-2.23).53.3% C and 46.7% T allele were distributed in stomach cancer cases,while 60.0% C and 40.0% T in controls.The OR for T allele in relation to C allele was 1.31 (1.02-1.69) when C allele was used as reference.In addition,the present study showed that MTHFR677 AnyT genotype might interact with smoking,moldy food intake,wheat porridge intake, eating salty food and Hp CagA infection to increase the risk of stomach cancer.No interaction was observed between MTHFR677 AnyT genotype and alcohol drinking or green tea intake.Conclusion MTHFR77 AnyT genotype,might increase the risk of stomach cancer development and the genotype might also interact with other environmental risk factors to increase the risk of stomach cancer. |
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