| 郭肖岩,何纳,姜庆五.日本血吸虫再感染危险因素的探讨[J].Chinese journal of Epidemiology,2004,25(8):691-694 |
| 日本血吸虫再感染危险因素的探讨 |
| Risk factor associated reinfection of Schistosoma japonicum |
| Received:July 10, 2003 |
| DOI： |
| KeyWord: 日本血吸虫 化疗 危险因素 非条件logistic回归分析 |
| English Key Word: Schistosoma japonicum Chemotherapy Risk factors Unconditional logistic regression analysi |
| FundProject: |
| Author Name | Affiliation | | Guo Xiaoyan | Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China | | He Na | Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China | | Jiang Qingwu | Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China |
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| Abstract: |
| 目的 探讨山丘型疫区日本血吸虫再感染的有关危险因素.方法 选取一山丘型疫区,随访观察居民吡喹酮普治后疫水接触及血吸虫再感染状况,对可能影响血吸虫再感染的有关因素进行非条件logistic回归分析.结果 多因素非条件logistic回归分析结果显示再感染与下列因素有关:化疗前每克粪便虫卵数(OR=2.066,95%CI:1.173～3.639),性别(OR=4.260,95%CI:1.275～14.235),4～10月份疫水接触平均指数B(OR=1.138,95%CI:1.045～1.240),性别与4～10月疫水接触平均指数B间的交互作用(OR=0.875,95%CI:0.817-0.982).结论 性别、化疗前感染度、疫水接触的持续时间及暴露面积与再感染的发生有关,其中性别与疫水接触之间尚存在弱的拮抗作用. |
| English Abstract: |
| Objective To explore the risk factors of Schistosoma japonicum reinfection afterchemotherapy in a hilly endemic area.Metho-ds In a hilly endemic area of S.japonica,data on contact to contaminated water and the rates of reinfection after mass praziquantel treatment were collected from residents who participated in a prospective cohort study on S.japonica.An unconditional logistic regress-ion analysis was performed to identify the risk factors associated with the reinfection of S.japonicum.Results Logistic regres-sion analysis data showed that three factors were associated with S.japonicum reinfection: eggs per gram stool (EPG) prior to chem-otherapy(OR=2.066,95 % CI:1.173-3.639),gender(OR=4.260,95%CI:1.275-14.235) and average degree of exposure (Index B) from April to October(OR=1 .138,95%CI:1.045-1.240).Interaction between gender and average exposure Index B from April to October was identified(OR=0.875,95%CI:0.817-0.982).Conclusion Eggs per gram stool (EPG) prior to chemotherapy ,level of exposure to infected water and gender were risk factors for reinfection with S.japonicum after chemotherapy.In addition, the-re appeared an antagonism between gender and level of exposure to infected water. |
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