吸烟、饮酒与食管癌p53基因改变的Meta分析

王波; 张艳; 徐德忠; 王安辉; 张磊; 孙长生; 李良寿

Abstract

王波,张艳,徐德忠,王安辉,张磊,孙长生,李良寿.吸烟、饮酒与食管癌p53基因改变的Meta分析[J].Chinese journal of Epidemiology,2004,25(9):775-778

吸烟、饮酒与食管癌p53基因改变的Meta分析

Meta-analysis on the relationship between tobacco smoking，alcohol drinking and p53 alteration in with esophageal carcinoma

DOI：

KeyWord: 食管肿瘤|基因，p53|Meta分析

English Key Word: Esophageal neoplasm|Gene,p53|Meta-analysis

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Author Name	Affiliation	E-mail
WANG Bo	Depurtntent of Epidemiology, Fourth Military Medicuf University Xi'an 710032 China
ZHANG Yan	陕西省血液中心
XU De-Zhong	Depurtntent of Epidemiology, Fourth Military Medicuf University Xi'an 710032 China	xudzh@fmmu.edu.cn
WANG An-hui	Depurtntent of Epidemiology, Fourth Military Medicuf University Xi'an 710032 China
ZHANG Lei	Depurtntent of Epidemiology, Fourth Military Medicuf University Xi'an 710032 China
SUN Chang-sheng	Depurtntent of Epidemiology, Fourth Military Medicuf University Xi'an 710032 China
LI Liung-shou	Depurtntent of Epidemiology, Fourth Military Medicuf University Xi'an 710032 China

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Abstract:

目的探讨吸烟、饮酒与食管癌p53基因改变之间的关系. 方法应用Meta分析对有关研究吸烟、饮酒与食管癌p53基因改变的文献进行综合评价. 结果纳入Meta分析的14篇研究吸烟的文献中, 吸烟与P53蛋白高表达、p53基因改变(P53蛋白高表达+p53基因突变)的合并OR值分别为1.99(95%CI:1.30～3.06)、1.64(95%CI:1.13～2.37)(P＜0.05), 吸烟与p53基因突变的合并OR值为1.11(95%CI:0.47～2.76)(P＞0.05).11篇研究饮酒的文献中, 饮酒与P53蛋白高表达、p53基因突变和p53基因改变的合并OR值分别为1.30(95%CI:0.83～2.04)、1.13(95%CI:0.67～1.90)和1.22(95%CI:0.87～1.72), 合并OR值无统计学意义(P＞0.05). 结论吸烟与p53基因改变有显著联系, 饮酒与p53基因改变未见显著联系.

English Abstract:

Objective To investigate the relationship between tobacco smoking, drinking and p53 alteration in esophageal carcinoma. Methods Literature on the relationship between p53 alteration in esophageal carcinoma and tobacco smoking, drinking through Meta-analysis were reviewed. Results In 14 selected papers related to tobacco smoking, pooled odds ratio(OR)of tobacco smoking with P53 over expression and p53 alteration were 1.99(95%CI:1.30-3.06)and 1.64(95%CI:1.13-2.37), respectively(P< 0.05). Pooled OR of tobacco smoking with p53 mutation was 1.11(95% CI:0.47-2.76)(P>0.05). In 11 selected papers on alcohol drinking, pooled OR of drinking with P53 overexpression, p53 mutation and p53 alteration were 1.30 (95%CI:0.83-2.04), 1.13 (95%CI:0.67-1.90) and 1.22(95%CI:0.87-1.72)respectively(P>0.05). Conclusion There were significant relations between tobacco smoking and p53 alteration while there were no significant relations between alcohol drinkine and p53 alteration.

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