| 胡春平,邵姣梅,严江涛,范巧,刘珍君,田橙,吴海林,李小平,汪道文.武汉市社区人群血浆同型半胱氨酸分布特征及影响因素的多元逐步回归分析[J].Chinese journal of Epidemiology,2004,25(11):945-948 |
| 武汉市社区人群血浆同型半胱氨酸分布特征及影响因素的多元逐步回归分析 |
| Study on the distribution of serum homocysteine and on multi-stepwise regression analysis of the associated factors in the population of community areas in Wuhan |
| Received:September 29, 2003 |
| DOI： |
| KeyWord: 血浆同型半胱氨酸 多元逐步回归分析 患病率 |
| English Key Word: Homocysteine Multi-stepwise regression analysis Prevalence rate |
| FundProject:国家重点基础研究发展规划“973”资助项目(G2000056901) |
| Author Name | Affiliation | E-mail | | HU Chun-ping | Department of Cardiology,Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology, Wuhan 430030, China | | | SHAO Jiao-mei | Department of Cardiology,Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology, Wuhan 430030, China | | | YAN Jiang-tao | Department of Cardiology,Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology, Wuhan 430030, China | | | FAN Qiao | Department of Cardiology,Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology, Wuhan 430030, China | | | LIU Zhen-jun | Department of Cardiology,Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology, Wuhan 430030, China | | | TIAN Cheng | 武汉重型船舶七一二研究所卫生科 | | | WU Hai-lin | 武汉重型船舶七○九研究所卫生科 | | | LI Xiao-ping | 武汉重型船舶七○一研究所卫生科 | | | WANG Dao-wen | Department of Cardiology,Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology, Wuhan 430030, China | dwwang@tjh.tjmu.edu.cn |
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| Abstract: |
| 目的 描述武汉市社区人群血浆同型半胱氨酸(Hcy)在不同性别、不同年龄段分布水平和分布特征及采用多元逐步回归分析方法分析人群Hcy的主要影响因素。方法 以武汉市三个社区的全部人群作为研究对象，对Hcy的分布特征及相关影响因素进行统计学分析。结果 (1)Hcy几何均数男性为14.43μmol/L，女性为10.89μmol/L，男性高于女性，两者差异有显著统计学意义(P<0.001)；(2)以年龄分层，每层男性Hcy水平亦高于女性，每层两者差异亦均有统计学意义；(3)武汉市社区人群高Hcy血症患病率为23.94%，男性患病率高于女性，是女性的2.62倍；(4)逐步回归分析显示，性别不同其Hcy的影响因素各不同，男性Hcy的影响因素有：日吸烟量、每周锻炼次数和尿微量白蛋白；女性的影响因素为：每次锻炼时间、体重、甘油三酯含量、高密度脂蛋白胆固醇、尿微量白蛋白和年龄。结论 (1)武汉市社区人群血浆Hcy水平呈偏态分布，存在年龄性别差异；(2)武汉市社区人群高Hcy患病率高于发达国家，亦高于国内其他一些城市；(3)武汉市社区人群血浆Hcy的主要影响因素存在性别差异，与国外报道和与国内其他地区报道有所不同，提示血浆Hcy水平还可能受到环境等有关因素的影响。 |
| English Abstract: |
| Objective To study the serum homocysteine(Hcy)distribution and characteristics in different sex and age groups in the community residents in Wuhan, and to analyse its associated factors with multi-stepwise regression analysis. Methods The population under study was from three community areas in Wuhan. Demographic distribution and the correlation with other risk factors of serum Hcy were analyzed statistically. Results (1)Geometric mean of serum Hey was 14.43 μmol/L in males and 10.89 μmol/L in females with P0.001. (2)Hcy of per age level in males was also higher(P0.001 ). (3) The prevalence rate of hyperhomocysteinemia was 23.94% in the qeneral population in Wuhan. The prevalence rate of hyperhomocysteinemia in males was 2.62 times higher than in females. (4)Multi-stepwise regression analysis showed that Hcy had different affecting factors in males and females. The affecting factors of Hcy in males were daily cigarettes smoking, urine micro-albumin(UMALB) and times of exercise per week. The affecting factors of Hcy in females were duration of exercise each time, weight,triglyceride(TG), high-density lipoprotein(HDL), urine micro-albumin(UMALB) and age. Conclusions (1)Hcy at the population level was significantly different by sex and age. (2)Population living in the community in Wuhan had a higher serum level and prevalence rate of Hcy comparing to some other cities in China and even in developed countries. (3)The important affecr.ing factors of Hcy in population also showed sex difference, unlike the reports from other countries or other areas in China. Serum Hcy seemed to be affected by environmental and other factors. |
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