| 邵中军,徐德忠,徐剑秋,门可,闫永平,张磊,张景霞.孕期性行为与乙型肝炎病毒宫内感染关系的病例对照研究[J].Chinese journal of Epidemiology,2005,26(4):232-235 |
| 孕期性行为与乙型肝炎病毒宫内感染关系的病例对照研究 |
| A retrospective study on the association of sexual behavior during pregnancy with intrauterine infection of hepatitis B virus |
| Received:December 05, 2004 |
| DOI： |
| KeyWord: 乙型肝炎病毒 性行为 宫内感染 |
| English Key Word: Hepatitis B virus Sexual behavior Intrauterine infection |
| FundProject:国家自然科学基金资助项目(30230320) |
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| Abstract: |
| 目的应用病例对照研究方法探讨孕期性行为与乙型肝炎病毒(HBV)宫内感染关系。方法以212例HBsAg阳性孕妇的连续性病例及其新生儿为研究对象,以外周血HBsAgAbbott检测S/N值≥5的新生儿为病例组,余为对照组,收集孕妇孕期性行为、母亲HBeAg状态及其他相关因素等流行病学资料,采用单因素分析、多因素logistic回归分析等方法探讨上述因素与HBV宫内感染关系。结果214例新生儿有10例新生儿发生宫内感染。孕中期性行为是HBV宫内感染的危险因素,OR值为9.15(1.10～76.28),且有剂量反应关系。既往确定的母亲HBeAg、HBVDNA阳性也是HBV宫内感染危险因素。交互作用分析提示孕中期性行为与母亲HBeAg有协同作用。结论孕中期性行为是HBV宫内感染新发现的危险因素,值得进一步研究。为预防HBV宫内感染应孕前抑制病毒复制,孕期节制性行为。 |
| English Abstract: |
| Objective Case-control study was employed to explore the association of sexual behavior during pregnancy and hepatitis B virus (HBV) intrauterine infection. Methods 212 HBsAg positive pregnant women were consecutively collected and investigated as objects. Those neonates detected for HBsAg with S/N value ≥5 by Abbott reagents in periphery sera were selected as cases, others as controls. Information on sexual behavior during pregnancy, maternal HBeAg status and other factors was collected, and were analyzed with univariate analysis, multivariate logistic regression analysis, etc, to explore the association of factors with HBV intrauterine infection. Results Ten of the 214 neonates were validated as occurrence of HBV intrauterine infection. Sexual behavior in the second trimester during pregnancy, with odd ratios 9.15 (95%CI: 1.10- 76.28 ), as well as maternal positivity for HBeAg and HBV DNA, was significantly associated with HBV intrauterine infection, and sequently affirmed by multiple logistic regression analysis. The strength of association increased with frequency of sexual behavior. Interaction analysis suggested that there was synergistic interaction between maternal positivity of HBeAg and sexual behavior in the second trimester. Conclusion Sexual behavior was a newly discovered risk factor for HBV intrauterine infection, which need to be estimated in future studies. Inhibition of virus replication and moderate control of sexual behavior would be helpful to prevent HBV intrauterine infection. |
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