| 徐芳英,董健康,朱益民,瞿美娟,汪芬娟,金以森,任国平,来茂德.结直肠癌独立预后因素:TNM分期、肿瘤芽、神经周围侵犯、瘤旁淋巴细胞浸润和尿糖[J].Chinese journal of Epidemiology,2005,26(5):366-369 |
| 结直肠癌独立预后因素:TNM分期、肿瘤芽、神经周围侵犯、瘤旁淋巴细胞浸润和尿糖 |
| Study on independent factors on the prognosis of colorectal carcinoma: TNM stage,tumor budding,perineural invasion,peritumoral-lymphocytic infiltration and urine glucose |
| Received:August 06, 2004 |
| DOI： |
| KeyWord: 结直肠肿瘤 预后 |
| English Key Word: Colorectal carcinoma Prognosis |
| FundProject: |
| Author Name | Affiliation | E-mail | | XU Fang-ying | Department of Pathology and Pathophysiology, Centre for Environmental Genomics, School of Medicine, Zhejiang University, Hangzhou 310031, China | | | DONG Jian-kang | 杭州市萧山区疾病预防控制中心 | | | ZHU Yi-min | Department of Pathology and Pathophysiology, Centre for Environmental Genomics, School of Medicine, Zhejiang University, Hangzhou 310031, China | | | QU Mei-juan | 杭州市萧山人民医院 | | | WANG Fen-juan | 杭州市萧山区疾病预防控制中心 | | | JIN Yi-sen | 杭州市萧山区疾病预防控制中心 | | | REN Guo-ping | 浙江大学附属第一医院 | | | LAI Mao-de | Department of Pathology and Pathophysiology, Centre for Environmental Genomics, School of Medicine, Zhejiang University, Hangzhou 310031, China | lmd@zju.edu.cn |
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| Abstract: |
| 目的 探讨临床因素与病理形态学因素对结直肠癌预后的影响. 方法 运用单因素及多因素Cox比例风险模型对226例结直肠癌的临床与病理形态学因素与预后的关系进行分析. 结果 单因素分析显示肿瘤浸润深度、脉管侵犯、神经周围侵犯、肿瘤芽、肿瘤间质淋巴细胞浸润、Crohn's样反应、转移淋巴结数目、远处转移、TNM分期、尿糖与预后有关. 多因素分析显示年龄大、TNM分期高、肿瘤芽级别高、存在神经周围侵犯、肿瘤间质淋巴细胞浸润少及尿糖阳性的相对危险度高. 结论 年龄、TNM分期、肿瘤芽、神经周围侵犯、肿瘤间质淋巴细胞浸润和尿糖是估计结直肠癌患者预后的独立指标. |
| English Abstract: |
| Objective To study the influence of clinical and pathological-morphological parameters on the prognosis of colorectal carcinoma. Methods Univariate and multivariate Cox proportional hazard model were used to study the influence of clinical and pathological-morphological factors on the prognosis in 226 colorectal carcinoma cases. Results Using univariate analysis, data showed that the factors significantly related to disease prognosis would include:the depth of direct spread, vessel invasion, perineural invasion, tumor budding, peritumoral-lymphocytic infiltration, Crohn-like reaction, number of positive lymph nodes, distant metastasis, TNM stage and urine glucose. Multivariate Cox proportional hazard model showed that six factors were identified to be associated with higher relative-risk(RR),including: older age, advanced TNM stage, more severe budding, perineural invasion, less peritumoral-lymphocytic infiltration and urine glucose. Conclusion Age, TNM stage, tumor budding, perineural invasive, peritumoral-lymphocytic infiltration and urine glucose were independent predictors to the prognosis of colorectal carcinoma. |
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