广州市2002-2003年1032例登革热患者流行病学特征分析

张复春; 陈燕清; 卢业成; 王建; 陈万山; 洪文欣

Abstract

张复春,陈燕清,卢业成,王建,陈万山,洪文欣.广州市2002-2003年1032例登革热患者流行病学特征分析[J].Chinese journal of Epidemiology,2005,26(6):421-423

广州市2002-2003年1032例登革热患者流行病学特征分析

Analysis on clinical and epidemiological characteristics of 1032 patients with Dengue fever in Guangzhou

Received:September 23, 2004

DOI：

KeyWord: 登革热临床特征流行病学

English Key Word: Dengue fever Clinical characteristic Epidemiology

FundProject:

Author Name	Affiliation	E-mail
ZHANG Fu-chun	Guangzhou Number 8 People’s Hospital, Guangzhou 510060, China	zfc8y@yahoo.com.cn
CHEN Yan-qing	Guangzhou Number 8 People’s Hospital, Guangzhou 510060, China
LU Ye-cheng	Guangzhou Number 8 People’s Hospital, Guangzhou 510060, China
WANG Jian	Guangzhou Number 8 People’s Hospital, Guangzhou 510060, China
CHEN Wan-shan	Guangzhou Number 8 People’s Hospital, Guangzhou 510060, China
HONG Wen-xin	Guangzhou Number 8 People’s Hospital, Guangzhou 510060, China

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Abstract:

目的分析广州地区登革热(DF)1型流行的临床及流行病学特征。方法对广州市第八人民医院2002年5月至2003年11月间收治的1032例DF患者的流行病学及临床资料进行回顾性分析,用细胞培养和逆转录聚合酶链反应(RTPCR)进行登革病毒分离和鉴定。结果1032例DF患者的年龄在55天龄～91岁,平均(34.7±13.2)岁,男女性别比为1.03∶1。该病的潜伏期为2-12天,平均为(5.3±2.4)天。发病高峰期为7-11月份,其中9月份发病数最多,占45.0%。主要爆发点有26个,共有病例675例,占全部病例的65.4%。主要临床表现为发热(100%)、头痛(90.9%)、全身肌痛(68.4%)、骨痛(48.8%)、疲乏(79.3%)、皮疹(60.1%)、束臂试验阳性(45.3%);白细胞及血小板减少分别占63.3%和60.8%。从54份血清标本中19份分离出病毒,经RTPCR和基因测序证实为登革病毒1型感染。基因序列分析表明,2003年流行株与登革病毒1型柬埔寨流行株及我国1997、1999年登革病毒1型流行株的同源性最高,分别为97%、97%、98%。结论广州地区2002-2003年流行的DF为登革病毒1型所致,多数病例符合典型DF的临床表现。

English Abstract:

Objective To analyze the clinical and epidemiolog ical char acteristics of Dengue fev er(DF) during t he Dengue 1 epidemic in Guang zhou. Methods Clinical and epidemiological data of 1032 patients with DF from May 2002 to November 2003 were retrospectively analyzed. Dengue virus were isolated by cell culture and t yped by reverse transcriptase polymerase chain reaction (RT PCR). Results Age of the patients r anged fr om 55 days to 91 y ears old (average 34.713.2 years) with sex r atio 1.03 1. Incubation period ranged from 2 to 12 days with mean per iods of 5.32.4 days. Most (45.0%)cases appeared in September and the epidemic last from July to No vember. Dengue outbreak had involued 675 cases in 26 common places. The common manifestations were seen as fev er (100%), headache(90.9%), myalg ia (68.4%), bone sor eness(48.8%), fatigue (79.3%), skin rash (60.1%), positive tourniquet test(45.3%), leukopenia(63.3%) and thrombocytopenia(60.8%), respect ively. Deng ue virus was isolated from serum of 19 out of 54 patients and identified as Dengue virus type 1. DNA sequence analyzes on rates of nucleotide homolog y were 97%, 97% and 98% compared with those of Dengue virus type 1 strain of DF outbreak in Cambodia, in 1997 and 1999 in China. Conclusion The epidemic of DF in Guang zhou in 2002/2003 was caused by Dengue v irus type 1 with most patients showing classic type of the disease. Date suggested that chang e can happen from non endemic to hypoendemic regions in Guangdong province.

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