| 张霞芬,林志益.浙江省舟山市269例海岛渔民病毒性肝炎型别分析[J].Chinese journal of Epidemiology,2005,26(8):595 |
| 浙江省舟山市269例海岛渔民病毒性肝炎型别分析 |
| Study on the safety and immunogenicity of enterotoxigenic Escherichia coli recombinant active vaccine |
| Received:March 28, 2005 |
| DOI： |
| KeyWord: 肠毒素大肠埃希菌 疫苗 免疫性 |
| English Key Word: Enterotoxigenic Escherichia coli Vaccine Immunogenicity |
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| Abstract: |
| 为探讨海岛渔民病毒性肝炎的病毒种类及其与临床的关系, 对 269 例海岛渔民肝炎患者的型别进行了分析。研究对象为浙江省舟山市人民医院 2001 年 1 月至 2004 年 12 月住院的 269例渔民病毒性肝炎患者, 均为男性, 年龄18~ 65岁, 平均32. 5岁。 |
| English Abstract: |
| Objective To study the safety, immunogenicity on the enterotoxigenic Escherichia coli(E.coli) recombinant active vaccine FE3 and FE16. Methods Toxicity and immunogenicity of the vaccine were determined by experiments on enterotoxigenic E.coli toxicity and immunological experiments on rabbits and mice. Results The results of an toxicological experiments were negative. The agglutination titer of antibodies against the S.flexneri 2a and enterotoxigenic E.coli plamid antigen were all higher than 1:640 and 1:1280 in the sera of rabbits. IgGin the serum went up remarkably, while sIgA against CFA/I was also decteted in the dejecta of mice immunized with active bacteria either orogastrically or intranasally. Simultaneously, sIgA was not detected in the dejecta of mice immunized with inactive bacteria either orogastrically or intranasally. Conclusion The enterotoxigenic E.coli recombinant active vaccine showed good safety and immunogenicity, inducing both humoral and mucosal immunity in mice. |
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