| 钱元淑,吕雯,隋丽华,王晶.人乳头状瘤病毒16 18、单纯疱疹病毒Ⅱ型和巨细胞病毒感染与宫颈癌发生、发展的关系[J].Chinese journal of Epidemiology,2005,26(8):622-625 |
| 人乳头状瘤病毒16 18、单纯疱疹病毒Ⅱ型和巨细胞病毒感染与宫颈癌发生、发展的关系 |
| Study on the relationship between genesis and development of cervical cancer and the infection of human papillomavirus type 16/18,human herpesvirus Ⅱ and cytomegalovirus |
| Received:February 01, 2005 |
| DOI： |
| KeyWord: 宫颈癌 人乳头状瘤病毒 单纯疱疹病毒 巨细胞病毒 宫颈上皮内瘤样病变 |
| English Key Word: Cervical cancer Human papillomavirus Human herpesvirus Cytomegalovirus Cervical intraepithelial neoplasia |
| FundProject: |
| Author Name | Affiliation | E-mail | | QIAN Yuan-shu | Departmentof Gynecology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China | | | LV Wen | Departmentof Gynecology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China | ww4021@163.com | | SUI Li-hua | 哈尔滨医科大学附属第三医院 | | | WANG Jing | 哈尔滨医科大学附属第三医院 | |
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| Abstract: |
| 目的探讨人乳头状瘤病毒(HPV)16/18、单纯疱疹病毒Ⅱ型(HSVⅡ)和巨细胞病毒(CMV)感染与宫颈癌发生、发展的关系。方法对43例宫颈癌、47例宫颈上皮瘤样病变(CIN)、56例宫颈炎和10例正常宫颈进行聚合酶链反应检测HPV16/18、HSVⅡ和CMV感染情况。结果HSVⅡ、HPV16/18和CMV的阳性率在宫颈癌和CIN组、CINⅢ级和CINⅠ～Ⅱ级组均有递减趋势,且差异有统计学意义。Ⅱ期宫颈癌组HPV16/18阳性显著高于Ⅰ期宫颈癌组,高分化宫颈癌组HPV16/18和HSVⅡ阳性高于中分化组,与临床分期及组织类型差异均无统计学意义;CMV阳性与临床分期、组织分级及组织类型差异均无统计学意义。三种病毒感染拷贝数,HSVⅡ和HPV16/18:宫颈癌>CIN>宫颈炎;CMV:宫颈癌>CIN。宫颈癌中出现几种病毒混合感染,其中HPV16/18合并HSVⅡ明显多于HPV16/18合并CMV者。结论HPV16/18、HSVⅡ和CMV感染与宫颈癌的发生发展关系密切,且与病毒负荷量有关,可能是宫颈癌的致病因子。 |
| English Abstract: |
| Objective To investigate the correlation between genesis and the development of cervical cancer and infection of human papillomavirus(HPV) type 16/18,human herpesvirusⅡ(HSV-Ⅱ)and cytomegalovirus(CMV). Methods Different viruses were determined by polymerase chain reaction in 156 specimens of uterine including cervix 43 cervical cancer specimens,47 cervical intraepithelial neoplasia(CIN) specimens, 56 cervicitis specimens and 10 normal cervix specimens. Results (1)Positive rates on different viruses: the positive rates of HSV-Ⅱ, HPV16/18 and CMV were declining in the cervical cancer specimens, CIN specimens or CIN Ⅲ specimens and CIN Ⅰ-Ⅱ specimens, with significant differences. (2)Positive rate and grading, staging and histogenesis of cervical cancer on different viruses as well as positive rates of HPV16/18 in Ⅱ staging cervical cancer specimens were significantly higher than that in Ⅰ staging cervical cancer specimens while positive rates of HPV16/18 and HSV-Ⅱ in high differentiation of cervical cancer specimens were significantly higher than those with medium differentiation from cervical cancer specimens. Positive rates of CMV did not seem to correlate with positive rate of HSV-Ⅱ and CMV was not correlated to grading, staging or histogenesis of cervical cancer. (3)Copies of infected virus, HSV-Ⅱ and HPV16/18 showing cervical cancerCIN cervicitis while with CMV:cervical cancerCIN. (4)There were mixed infections of different viruses as HPV16/18+HSV-Ⅱ HPV16/18+CMV seen in the study. Conclusion HPV 16/18, HSV-Ⅱ and CMV infection were closely related to the genesis of cervical cancer and quantity of viruses which might have played an important role in carcinogenesis of cervical lesions. |
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