| 秦江梅,李锋,谭晓华,郭淑霞,王小波,张万江,谢建新,黄瑾,普雄明,芮东升,杨磊.新疆地区经典型卡波氏肉瘤相关因素的病例对照研究[J].Chinese journal of Epidemiology,2005,26(9):673-675 |
| 新疆地区经典型卡波氏肉瘤相关因素的病例对照研究 |
| A case-control study on risk factors of classic Kaposi’s sarcoma in Xinjiang |
| Received:February 05, 2005 |
| DOI： |
| KeyWord: 经典型卡波氏肉瘤 疱疹病毒8型 病例对照研究 危险因素 |
| English Key Word: Kaposi’s sarcoma Human herpevirus 8 Case-control study Risk factor |
| FundProject:国家自然科学基金资助项目(30160082) |
| Author Name | Affiliation | E-mail | | QIN Jiang-mei | Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi University, Shlhezi 832002, China | | | LI Feng | Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi University, Shlhezi 832002, China | | | TAN Xiao-hua | Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi University, Shlhezi 832002, China | | | GUO Shu-xia | Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi University, Shlhezi 832002, China | | | WANG Xiao-bo | Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi University, Shlhezi 832002, China | | | ZHANG Wan-jiang | Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi University, Shlhezi 832002, China | | | XIE Jian-xin | Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi University, Shlhezi 832002, China | | | HUANG Jin | Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi University, Shlhezi 832002, China | | | PU Xiong-ming | 新疆维吾尔自治区人民医院皮肤科 | | | RUI Dong-sheng | Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi University, Shlhezi 832002, China | | | YANG Lei | Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi University, Shlhezi 832002, China | yanglei62@yahoo.com |
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| Abstract: |
| 目的 分析新疆经典型卡波氏肉瘤相关危险因素。方法 利用新疆8个地州市随访的经典型卡波氏肉瘤病例,按同性别、同民族、年龄相差≤5岁、同一个居住地区配对要求,1:4选取对照,开展病例对照研究,采用条件logistic回归进行统计分析。结果 单因素分析显示:白细胞介素、血管内皮生长因子、β2微球蛋白(β2-MG)、新喋呤和8型疱疹病毒(HHV-8)等5个相关因素与经典型卡波氏肉瘤有关系。β2-MG和HHV-8两项危险因素进入了多因素条件logistic回归模型,其OR值分别为1.002(95%CI:1.000～1.003)、81.041(95%CI:1.790～3669.620)。结论 β2-MG与经典型卡波氏肉瘤的发生呈正相关关系,HHV-8感染是经典型卡波氏肉瘤独立的危险因素。 |
| English Abstract: |
| Objective To analyse related risk factors of classic Kaposi’s sarcoma in Xinjiang. Methods A 1:4 case-control study was used and the conditional logistic regression model was performed in this study. Cases were followed up in Xinjiang while controls were selected by the same sex, nation and age within 5 years with cases. Results Interleukin-6, vascular endothelial growth factor,p2-MG, neopterin, human herpevirus 8,were found to be associated with Kaposi ’ s sarcoma risk in one-way variance model while P2-MG and human herpevirus 8 entered the multiple conditional logistic regression model, and their OR s were 1.002(95 % C/ ： 1.000-1.003),81.041(95 % CI：l. 790-3669.620). Conclusion There was a correlate relationship between p2-MG and classic Kaposi’s sarcoma being found that human herpevirus 8 exposure related factors seemed to have played important roles on classic Kaposi’s sarcoma in Xinjiang. |
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