谷氨酸脱羧酶抗体在初诊成人2型糖尿病患者中的阳性率及其分布特点

李霞; 周智广; 黄干; 彭健; 颜湘; 杨琳; 王建平; 邓志明

Abstract

李霞,周智广,黄干,彭健,颜湘,杨琳,王建平,邓志明.谷氨酸脱羧酶抗体在初诊成人2型糖尿病患者中的阳性率及其分布特点[J].Chinese journal of Epidemiology,2005,26(10):800-803

谷氨酸脱羧酶抗体在初诊成人2型糖尿病患者中的阳性率及其分布特点

Study on the positive frequency and distribution of glutamic acid decarboxylase antibody in phenotypic type 2 diabetic patients

Received:March 14, 2005

DOI：

KeyWord: 糖尿病，2型谷氨酸脱羧酶抗体成人隐匿性自身免疫糖尿病

English Key Word: Phenotypic type 2 diabetes Glutamic acid decarboxylase antibody Latent autoimmune diabetes in adults

FundProject:湖南省科技厅重点项目(03SSY1009)面上项目(02SSY3065)；湖南省卫生厅重点项目(2001-Z04)基金资助

Author Name	Affiliation	E-mail
LI Xia	Diabetes Centre, Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
ZHOU Zhi-guang	Diabetes Centre, Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China	zhouzg@hotmail.com
HUANG Gan	Diabetes Centre, Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
PENG Jian	Diabetes Centre, Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
YAN Xiang	Diabetes Centre, Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
YANG Lin	Diabetes Centre, Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
WANG Jian-ping	Diabetes Centre, Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
DENG Zhi-ming	Diabetes Centre, Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China

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Abstract:

目的探讨谷氨酸脱羧酶抗体(GAD－Ab)在初诊成人2型糖尿病患者中的阳性率及其分布特点。方法用放射配体法检测2035例临床初诊为2型糖尿病(T2DM)患者的GAD－Ab，分析GAD－Ab的阳性率及其分布与临床特征的关系。结果 ①成人隐匿性自身免疫糖尿病在以医院为基础、初诊T2DM患者中的患病率为7．1％(145／2035)，与在欧美高加索人中进行的大规模研究UKPDS 的结果差异无统计学意义(8．7％vs．9．8％，P=0．391)，而高于ADOPT研究(8．0％vs．4．2％，P= 0．000)和日本的Ehime研究结果(7．1％vs．3．8％，P=0．000)；②GAD－Ab的阳性率和滴度分布与起病年龄、体重指数和空腹C肽等临床特征有关，起病年龄小、体重指数低和空腹C肽低者具有较高的阳性率和滴度。结论 ①中国成人初诊T2DM患者的GAD－Ab阳性率与欧美高加索人接近，而高于日本人群；②GAD－Ab的阳性率和滴度与糖尿病患者的临床特征存在关联。

English Abstract:

Objective To investigate the positive frequency and distribution of glutamic acid decarboxylase antibody(GAD-Ab) in phenotypic type 2 diabetic(T2DM) patients. Methods Sera of 2035 phenotypic T2DM patients were screened for GAD-Ab with radioligand assay. The positive frequency of GAD-Ab and its relation with cinical features were analyzed. Results (1)The positivity of GAD-Ab in clinic-based,phenotypic T2MD patients was 7.1%(145/2035),comparable to that of data from Caucasians as shown by UKPDS(8.7％vs.9.8％，P=0.391), and ADOPT (8.0％vs.4.2％，P= 0.000) but higher than that of Japanese in Ehime study(7.1％vs.3.8％，P=0.000).(2) The positive frequency and distribution of GAD-Ab titer were related to clinical features, including age at onset, body mass index (BMI) and fasting C peptide levels. Patients with younger age at onset((0.34vs.0.11,P＜0.05), less BMI(0.33vs.0.10,P＜0.05) and lower C peptide levels(0.38vs.0.11,P＜0.05) would have higher GAD-Ab titers. Conclusion (1)The positivity of GAD-Ab in adult-onset phenotypic T2DM in Chinese was similar to that of Caucasians but hight that of the Japanese. (2)The distribution of GAD-Ab titers was associated with clinical features, with high GAD-Ab titers for those having younger age at onset, less BMI and lower C peptide levels.

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