| 何寒青,陈坤,张扬,童峰,范春红,宋亮.谷胱甘肽转移酶M1基因多态性与大肠癌发生关系的多水平Meta回归分析[J].Chinese journal of Epidemiology,2005,26(12):992-994 |
| 谷胱甘肽转移酶M1基因多态性与大肠癌发生关系的多水平Meta回归分析 |
| Glutathione S-transferase M1 polymorphism and the risk on colorectal caner: a multilevel Meta regression |
| Received:May 30, 2005 |
| DOI： |
| KeyWord: 谷胱甘肽转移酶M1基因 基因多态性 大肠肿瘤 Meta回归分析 |
| English Key Word: Glutathione S-transferase M1 Genetic polymorphism Colorectal neoplasms Metaregression |
| FundProject:国家自然科学基金(30471492) |
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| Abstract: |
| 目的 探讨谷胱甘肽转移酶(GST)M1基因多态性与大肠癌发生的关系及其影响因素。方法采用多水平Meta回归分析方法进行合并效应值估计和异质性相关因素的研究。结果GSTM1基因多态性与大肠癌发生有关(合并OR值为1.17.95%CI：1.08～1.26)，种族类别、人群GSTM1基因基线缺失率等为研究间异质性的相关因素(P<0.05)；分层回归中，亚洲人、高加索人及低基线缺失水平人群(50%以下)中的GSTM1基因缺失型是大肠癌发生的危险因素(合并OR值分别为1.14、1.25、1.29)，结果具有统计学意义(P<0.05)。 GSTM1纯合缺失型是大肠癌发生的危险因素，并与人群的GSTM1基线缺失率和种族类别有关。 |
| English Abstract: |
| Objective In order to investigate the relationship between Glutathione S-transferase M1 (GSTMl) status and the risk on colorectal cancer as well as to detect the related factors to this association.Methods A pooled analysis of multilevel Meta-regression was performed to estimate GSTMl deficiency associated with the risks of colorectal cancer.Then subgroup Meta-regression was undertaken to evaluate the possible relationship between heterogeneity and the related characteristics.Results The overall pooled odds ratios of colorectal cancer risk associated with GSTM1 deficiency was 1.17(95% C7:l.08-1.26).Ethnicity, percent of GSTM1 deficiency in population had significant relationships with heterogeneity across the studies (P0.05).Results of subgroup Meta-regression showed that GSTMl deficiency was significantly associated with colorectal cancer risk in ethnic subgroups of Asians, Caucasians and in low level (lower than 50%) of GSTMl deficiency population( P 0.05).The respective pooled ORs were 1.14, 1.25 and 1.29.Conclusion GSTMl deficiency seemed to be a risk factor for colorectal cancer, while interactions on the characteristics of ethnicity, percentage of GSTMl deficiency in the studied population were related to this association. |
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