| 易洪刚,陈峰,于浩,赵杨,娄东华.病例同胞对照设计[J].Chinese journal of Epidemiology,2006,27(2):170-173 |
| 病例同胞对照设计 |
| Introduction on“case-sibling control design” |
| Received:September 08, 2005 |
| DOI： |
| KeyWord: 病例同胞对照设计 关联 连锁 基因 |
| English Key Word: Case2sibling control design Association Linkage Gene |
| FundProject:国家重点基础研究发展计划(973)资助项目(2002CB512910);国家自然科学基金资助项目(30571619);江苏省高校自然科学基金重点项目资助(04KJB310081) |
| Author Name | Affiliation | E-mail | | Yi Honggang | Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China | | | Chen Feng | Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China | ohcepf@163.com | | Yu Hao | Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China | | | Zhao Yang | Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China | | | Lou Donghua | Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China | |
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| Abstract: |
| 目的介绍病例同胞对照设计的研究设计及统计分析方法,并对实际资料进行统计分析。方法以亚甲基四氢叶酸还原酶基因C677T突变与冠心病连锁研究为实例,采用同胞-传递不平衡检验(s-TDT)和同胞组不平衡检验(SDT)等方法进行统计分析。结果采用s-TDT分析,统计量Z=0.27,P>0.05;采用SDT分析,χ2=0.31,P>0.05。提示受累子代与非受累子代T等位基因分布差异无统计学意义。结论病例同胞对照设计使用患者同胞作为对照,避免了人群分层现象,可以用来检测基因与疾病之间的关联或连锁。 |
| English Abstract: |
| Objective To introduce the design and statistical methods of case2sibling control design and to analyze the published data. Methods Data from an association study between the coronary heart disease and methylenetetrahydrofolate reductase gene C677T polymorphism was analyzed by the sib transmissionPdisequibrium test (s2TDT) and the sibship disequilibrium (SDT) methods. Results Using s2TDT method, Z value was 0. 27 with P > 0. 05. The result of SDT method showed that chi2square was 0. 31 with 1 df, P > 0. 05. All results suggested that neither s2TDT nor SDT showed significant difference between the transmitted and untransmitted methylenetetrahydrofolate reductase gene C677T allele distributions. Conclusion Case-sibling control design might avoid population stratification by using siblings as controls thus might be used to test association and linkage between genes and disease |
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