| 朱虔兮,边建超,沈强,汤洪伟,张宏伟,吴毅.乳头状甲状腺癌的配对病例对照研究[J].Chinese journal of Epidemiology,2006,27(5):416-419 |
| 乳头状甲状腺癌的配对病例对照研究 |
| A matched case-control study of papillary thyroid carcinoma |
| Received:September 15, 2005 |
| DOI： |
| KeyWord: 乳头状甲状腺癌 配对病例对照研究 危险因素 保护因素 |
| English Key Word: Papillary thyroid carcinoma Matched case-mntrol study Risk factors Protective factors |
| FundProject:国家自然科学基金资助项目(30371236) |
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| Abstract: |
| 目的探讨乳头状甲状腺癌(PTC)的危险因素。方法采用以医院为基础的配对病例对照研究,按性别、年龄(±3岁)和籍贯配对,共收集205对病例和对照,进行统一的问卷调查。用 Epi Info 6．0建立数据库,用SPSS 11．5软件进行单因素和多因素条件logistic回归分析。结果多因素条件logistic回归分析表明,经常饮茶和20年前经济水平高是PTC的保护因素,OR值分别为 0．456和0．221;CT检查史、肿瘤家族史和出生时母亲年龄≤22岁是PTC的危险因素,OR值分别为 12．935、7．027和3．729。对女性研究对象进行的多因素条件logistic回归分析显示,CT检查史、出生时母亲年龄≤22岁和妇科疾病史是PTC的危险因素,OR值为107．453、29．246和59．521;经常吃豆制品和20年前经济水平高是PTC的保护因素,OR值分别为0．025和0．144。结论 CT检查史、肿瘤家族史和出生时母亲年龄≤22岁是PTC的危险因素;经常饮茶和20年前经济水平高是PTC的保护因素;CT检查史、出生时母亲年龄≤22岁和妇科疾病史是女性PTC的危险因素;经常吃豆制品和 20年前经济水平高是女性PTC的保护因素。 |
| English Abstract: |
| Objective In order to explore the risk factors of the papillary thyroid carcinoma(PTC)，a hospital-based matched case-control study was carried out in Shanghai. Methods Matched by gender,age (士3 years old) and native place,205 pairs of cases and controls were recruited and studied. Database was established with Epi Info 6.0 software. Univariate and multivariate conditional logistic regression analysis were carried out with SPSS 11.5 software. Results Data from multivariate conditional logistic regression analysis showed that often drinking tea and having better economic living standard 20 years ago were protective factors of PTC,with ORs of 0.456 and 0.221 respectively. Personal history of CT examination,familial history of cancer and the mother' s age was older than 22 years when the research subject was delivered, were risk factors of PTC,with ORs of 12.935,7.027 and 3.729 respectively. Results data from multivariate analysis on female subjects showed that the history of CT examination,mother's age was older than 22 (when the subject was delivered) and the history of gynecological disease were the risk factors of PTC,with ORs of107.453,29.246 and 59.521 respectively. Taking bean products frequently and having higher standard of living 20 years ago were the protective factors of PTC, with ORs of 0.025 and 0. 144 respectively. Conclusion History of CT examination,familial history of cancer and the mother's age(older than 22 when the subject was delivered) were the risk factors of PTC. Frequent tea drinking habit and having higher standard of living 20 years ago were the protective factors of PTC. History of CT examination,mother's age(older than 22 when the subject was delivered) and the history of gynecological disease appeared the risk factors of PTC for women. Habit on frequent bean products taking and had higher standard of living 20 years ago were the protective factors of PTC to women. |
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