东亚人群NRAMP1基因多态性与结核易感性的Meta分析

李洪涛; 黄勤欢; 吕波; 黄瑾; 张天托

Abstract

李洪涛,黄勤欢,吕波,黄瑾,张天托.东亚人群NRAMP1基因多态性与结核易感性的Meta分析[J].Chinese journal of Epidemiology,2006,27(5):428-432

东亚人群NRAMP1基因多态性与结核易感性的Meta分析

Mete-analysis on NRAMPI gene polymorpbisms and tuberculosis susceptibility in Esst-Asia population

Received:October 13, 2005

DOI：

KeyWord: 结核多态现象(遗传学) 基因,NRAMP1 Meta分析人种群

English Key Word: Tuberculosis Polymorphism(Genetics) NRAMPI gene Meta-analysis Ethnic Groups

FundProject:

Author Name	Affiliation	E-mail
LI Hong-tao	Department of Respiratory Medicine, the Fifth Affiliated Hospital of SUN Yat-sen University, Zhuhai 519000, China
ZHANG Tian-tuo	Department of Respiratory Medicine, the Fifth Affiliated Hospital of SUN Yat-sen University, Zhuhai 519000, China
HUANG Qin-huan	Department of Respiratory Medicine, the Fifth Affiliated Hospital of SUN Yat-sen University, Zhuhai 519000, China
LV Bo	Department of Respiratory Medicine, the Fifth Affiliated Hospital of SUN Yat-sen University, Zhuhai 519000, China	huangjin1960@163.com
HUANG Jin	中山大学附属第三医院呼吸内科

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Abstract:

目的应用Meta分析探讨东亚人群NRAMP1基因3个多态性位点与结核易感性的关系。方法应用主题词和关键词“NRAMP1”、“SLC11A1”、“tuberculosis”和“结核”,检索1995年1 月至2005年5月Medline、Ovid及CBM disc数据库发表的有关文献,并辅以文献追溯的方法。结果结核病组和对照组3’UTR、D543N和INT4位点的多态现象同最常见纯合子基因型频率比值比 (OR)的合并OR值分别为1．68(95％CI:1．31-2．16,P<0．001);1．78(95％CI:1．38-2．30,P< 0．001);1．56(95％CI:0．72-3．35,P=0．26)。Egger线性回归分析提示3’UTR和D543N基因型相关文献没有发表偏倚,INT4基因型相关文献有一定的出版偏倚。结论东亚人群NRAMP1基因3’ UTR和D543N多态性位点与结核易感性相关;INT4多态性位点与结核易感性无统计学意义。

English Abstract:

Objective To provide a quantitative summary in estimating the association between polymorphisms of 3 loci in NRAMPI gene and susceptibility to tuberculosis in East-Asia population by means of meta-analysis. Methods We searched databases (MEDLINE,OVID and CBM disc) from January 1995 to May 2005 using "NRAMPI" or "SLC11A1",in combination with "tuberculosis",also performed a manual search of citations from relevant original studies and literature. For each study involved, information was wllected concerning the characteristics of the subjects, such as mean age of cases and the size of study. These characteristics were used to evaluate the sources of variation. Summary ORs and corresponding 95 % CI were estimated by fixed effects ( Mantel-Haenszel) or random effects ( DerSimonian and Laird) model. To check for publication bias,a funnel plot, using Egger's linear regression method，was constructed. Cumulative meta-analysis was performed to evaluate whether the summary OR for studies with the polymorphisms of the 3 loci in the NRAMPI gene was changing along with the accumulation of more data Chi-square goodness of fit was used to test deviation from Hardy-Weinberg equilibrium. Results Eight publications, with the number of cases and controls of 1067 and 1084 respectively,were identified and all genotype frequencies were consistent with Hardy-Weinberg equilibrium. The summary ORs for studies with polyinorphisms of 3' UTR, D543N and INT4 loci of the NRAMPI gene among the East-Asia population were 1.68(95 % CI:1.31一2.16，P< 0.001)，1.78 ( 95 % CI:1.38-2. 30，P< 0.001),1.56 (95%CI:0.72-3.35，P=0.26)，respectively when compared with their corresponding common homozygotes. Publication bias was not found in the studies with the three loci，except for INT4 locus, by Egger linear regression method. The cumulative summary effects ORs were 1.85 ( P=0.02) in 2000,1.35(P=0.12 ) in 2002，1.64(P=0.001)in 2003，and 1.68(P<0.001)in 2004 for 3" UTR locus, 1.88 (P=0.001)in 2000,1.65 ( P=0.001)in 2002，1.70(P<0.001)in 2003，1.76(P<0.001)in 2004, and 1.78 ( P < 0. 001) in 2005 for D543N locus, and 0. 88 ( P=0:70) in 2002,2.50(P=0.41)in 2003,1.52 ( P=0.42) in 2004 and 1.56 ( P=0.26) in 2005 for INT4 loucs.Conclusion Polymorphisms at 3" UTR and D543N loci had statistically significant association between the NRAMPI variants and susceptibility to tuberculosis in the East-Asia descendants, and variant in the INT4 locus failed to show statistically significant association in the East-Asia population.

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