1020名社区人群同型半胱氨酸水平的调查和相关分析

黄海威; 郭明辉; 黄家星; 林锐金; 张颖; 陈亚利

Abstract

黄海威,郭明辉,黄家星,林锐金,张颖,陈亚利.1020名社区人群同型半胱氨酸水平的调查和相关分析[J].Chinese journal of Epidemiology,2006,27(8):721-724

1020名社区人群同型半胱氨酸水平的调查和相关分析

The analysis of plasma homocysteine among 1020 residents in community

Received:May 02, 2006

DOI：

KeyWord: 同型半胱氨酸经颅多普勒血脂脑动脉狭窄

English Key Word: Homocysteine Transcranial doppler Blood lipid, Cerebral artery stenosis

FundProject:广东省科技计划资助项目(2004B33801002)

Author Name	Affiliation
HUANG Hai-wei	Department of Neurology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China
GUO Ming-hui	Department of Neurology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China
HUANG Jia-xing	香港中文大学威尔斯亲王医院内科及药物治疗系
LIN Rui-jin	广东省佛山市顺德区容奇医院；
ZHANG Ying	广东省佛山市顺德区容奇医院；
CHEN Ya-li	广东省佛山市顺德区容奇医院；

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Abstract:

目的描述社区人群血浆同型半胱氨酸(Hcy)在不同年龄和性别间的分布特征,探讨Hcy与血脂水平等之间的相关性,研究高Hcy血症的危险因素及其对脑动脉狭窄的影响。方法从2500名社区人群筛选出1020名无心脑血管病史并可以进行经颅多普勒(TCD)检查的人群为样本,记录吸烟饮酒史、血压、人体测量学和生化资料,采用荧光生化法测定血浆Hcy水平,使用SPSS 12.0软件对检测指标进行处理。结果社区人群中Hcy水平男性(15．0μmol/L±5．8μmol／L)高于女性(12 4μmol／L±3．9μmol／L),差异有统计学意义(P<0．05);Hcy水平随着年龄增长而增高(P< 0．05);高Hcy血症的发生率男性(47．2％)高于女性(23．2％),差异有统计学意义(P<0．05);大脑中动脉狭窄组中Hcy水平(18．3μmol／L±5．3μmol/L)高于非狭窄组(12．9μmol／L±4．6μmol／L); logistic回归分析证实Hcy水平与血脂等之间无相关性,而仅与性别和年龄相关(P<0．05)。结论社区人群中Hcy水平存在性别和年龄的差异,两者是高Hcy血症的独立危险因素,Hcy水平与血脂等诸因素无相关性,高Hcy血症易致脑动脉狭窄。

English Abstract:

Objective To study the plasma homocysteine(Hcy)distributive characteristics in different sex and age groups of the community residents in Guangdong, and to analyze its associated factors as well as its effects on cerebral artery stenosis.Methods In this study, we presented data concerning 2500 residents who had undergone a systematic health checkup,imludiug clinical and biologic examinations. Plasma was saved from 1020 residents who were asymptomatic but having TCD examination. Hcy concentration was measured by fluorescence ration biochemical assay kit.Results The average plasma Hcy levels of males(15.0 pmol/L士5.8 }mol/L)were significantly higher than those of females (12. 4 pmol/ I士3.9 pmol/L, P< 0.OS).Hcy level increased parallel with age. The prevalence rate of hyperhomocysteinemia in males(a}.2%)was higher than in females(23.2%).Hcy levels in MCA stenosls group(I8.3 }mol/I土5.3 Fcmol/I)were significantly higher than that in control group (I2.9 pmol/L士a.6 pmol/L, P< 0.OS).Based on logistic regression analysis, Hcy was only associated with sex and age, but not with blood lipids etc.Conclusion Hcy levels were different in sex and age groups which emerged as independent predictors of hyperhomocysteinemia but had no association with blood lipids in the community residents, suggesting that hyperhomocysteinemia might worsen cerebral artery Stenosis

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