| 时景璞,黄蓓婷,王海龙,贾志梅,付凌雨,李辉,董卫,董亚珞,周波,姜玉山,王文利,李继光.不同血清铁水平与原发性高血压关系的研究[J].Chinese journal of Epidemiology,2006,27(9):761-764 |
| 不同血清铁水平与原发性高血压关系的研究 |
| Research on the association between different levels of serum iron and essential hypertension |
| Received:March 13, 2006 |
| DOI： |
| KeyWord: 高血压,原发性 血清铁 危险因素 横断面研究 |
| English Key Word: Essential hypertension Serum iron Risk factor Cross-sectional study |
| FundProject:辽宁省教育厅基金资助项目(2004B008);辽宁省科技厅资助项目(2005225010) |
| Author Name | Affiliation | | SHI Jing-pu | Department of ClinicaL Epiderniology First Affiliated Hospital,China Medical University,Shenyang 110001, China | | HUANG Bei-ting | Department of ClinicaL Epiderniology First Affiliated Hospital,China Medical University,Shenyang 110001, China | | WANG Hai-long | Department of ClinicaL Epiderniology First Affiliated Hospital,China Medical University,Shenyang 110001, China | | JIA Zhi-mei | Department of ClinicaL Epiderniology First Affiliated Hospital,China Medical University,Shenyang 110001, China | | FU Ling-yu | Department of ClinicaL Epiderniology First Affiliated Hospital,China Medical University,Shenyang 110001, China | | LI Hui | Department of ClinicaL Epiderniology First Affiliated Hospital,China Medical University,Shenyang 110001, China | | DONG Wei | Department of ClinicaL Epiderniology First Affiliated Hospital,China Medical University,Shenyang 110001, China | | DONG Ya-luo | Department of ClinicaL Epiderniology First Affiliated Hospital,China Medical University,Shenyang 110001, China | | ZHOU Bo | 辽宁省彰武县卫生局 | | JIANG Yu-shan | 中国医科大学附属第一医院院办公室 | | WANG Wen-li | 中国医科大学附属第一医院院办公室 | | LI Ji-guang | |
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| Abstract: |
| 目的探讨辽宁省彰武县农村人群不同血清铁水平与原发性高血压(EHT)的关系.方法在彰武县农村用整群多级随机抽样的方法调查18岁以上人口4372人.调查对象测量血压,采用统一的调查表调查相关因素;现场每人采空腹静脉血5 ml,检测血清铁、胆固醇、甘油三酯、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清钠、血清钾、血清钙水平;以入选对象中所有EHT患者作为病例组,正常者作为对照组进行病例对照研究.用Fox Pro软件建立数据库,资料分析用SPSS 10.0软件.结果EHT组的血清铁浓度大于正常血压组,高血压组为(17.75±7.66)μmol/L,正常组为(17.23±7.83)μmol/L,差异有统计学意义(P<0.05),血清铁水平在高舒张压(DBP)组和正常DBP组各为(17.84±7.58)μmol/L、(17.26±7.85)μmol/L,差异也有统计学意义(P<0.05);单因素分析发现,血清铁水平增高是EHT、DBP和收缩压(SBP)的危险因素,经对EHT多因素分析后,血清铁仍是高血压的危险因素(OR=1.296,95%CI:1.057~1.590);高SBP的多因素分析结果显示,血清铁也是高SBP的危险因素(OR=1.285,95%CI:1.102~1.498).高DBP多因素分析结果显示血清铁没有进入模型.结论血清铁水平可能是EHT的一个危险因素. |
| English Abstract: |
| Objective To study the relationship between serum iron(SI) and essential hypertension(EHT) based on population-based samples. Methods Using clustering multistage sampling method,all the people above 18 years old in the target population were investigated. Blood pressure was measured and the questionnaire was used to find out related factors. Five milliliters fast vein blood were drawn and the serum were used for testing on serum iron(SI) and other elements such as blood sugar, cholesterol(CHOL ),triglyceride (TG),high density lipoprotein(HDL-C) ,low density lipoprotein(LDL-C) ,serum sodium,serum potassium,serum calcium etc. A case control study was carried out with EHT patients from the selected population as case group,and the other healthy peoples as controls. Database was crE;ated by Fox Pro and SPSS 10.0 was used for statistical analysis.Results The concentrations of SI,with(17.75士7. 66 ) pmol}L in EHT group and(17.23士7.33)}emol/L in control group,showed statistical difference(P<0.O5)between the two groups. The concentrations of SI also showed statistical difference(P<0. 05 ) between the high DBP and normal group with the average level as(17.84士7.58)}rmo1}L in high DBP group and(17.26土7.85)umoI/L in normal group. Data from monovariate analysis showed that the increase of SI was a risk factor for EHT,DBP and SBP. By multivariate analysis for ET,while SI still existed in the model( OR=1.296.95%CI:1.057-1.590),but for 5BP the results almost remained the same(OR=1.285,95%CI:1.102-1.498).ConclusionData from the results showed that SI was probably a risk factor for EHT. |
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