感染乙型肝炎病毒不同基因型和亚型患者的临床特点分析

赵鸿; 李俊; 李兴丰; 斯崇文; 于敏; 公维波; 于岩岩; 王贵强

Abstract

赵鸿,李俊,李兴丰,斯崇文,于敏,公维波,于岩岩,王贵强.感染乙型肝炎病毒不同基因型和亚型患者的临床特点分析[J].Chinese journal of Epidemiology,2007,28(1):74-77

感染乙型肝炎病毒不同基因型和亚型患者的临床特点分析

Clinical characteristies and distribution of hepatitis B virus genotype and sub-genotype

Received:August 15, 2006

DOI：

KeyWord: 乙型肝炎病毒基因型基因亚型

English Key Word: Hepatitis B virus Genotype Sub-type

FundProject:卫生部临床学科重点项目(20010911)；美国cMB基金；北京大学“985”项目

Author Name	Affiliation	E-mail
ZHAO Hong	Department of Infectious Diseases, First Teaching Hospital of Peking University, Beijing 100034, China
LI Jun	Department of Infectious Diseases, First Teaching Hospital of Peking University, Beijing 100034, China
LI Xing	Department of Infectious Diseases, First Teaching Hospital of Peking University, Beijing 100034, China
feng	Department of Infectious Diseases, First Teaching Hospital of Peking University, Beijing 100034, China
SI Changwen	Department of Infectious Diseases, First Teaching Hospital of Peking University, Beijing 100034, China
YU Min	Department of Infectious Diseases, First Teaching Hospital of Peking University, Beijing 100034, China
GONG Weibo	Department of Infectious Diseases, First Teaching Hospital of Peking University, Beijing 100034, China
YU Yanyon	Department of Infectious Diseases, First Teaching Hospital of Peking University, Beijing 100034, China	wanggq@hotmail.com

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Abstract:

目的明确乙肝病毒不同基因型和亚型在国内的分布及其与病情的相关性。方法收集来自国内8个地区884例慢性乙型肝炎病毒感染者的血清和临床资料，用PCR—RFLP方法鉴定病毒基因型和亚型，分析不同基因(亚)型与病情间的相关性。结果乙肝病毒B(20．77％)和C(78．22％)基因型为最常见，仅1例为D基因型；所有B基因型均为Ba亚型，C基因型中仅发现C2和C1亚型。北方地区患者多感染C基因型(83．62％)／C2亚型(90．32％)。B基因型患者的年龄明显小于c基因型患者(P<0．000)。不同年龄段B基因型和c基因型比较发现，感染B基因型的患者在30岁以下、30～50岁和50岁以上年龄段中所占比例逐渐下降，感染C基因型的患者比例呈现相反趋势(P=0．000)。C1和c2亚型患者的年龄相近。各基因型在肝硬化、慢乙肝和无症状携带者中的分布无差别。B和c基因型(c1和C2亚型)患者的病毒量之间无差别。B基因型患者的肝脏炎症和纤维化评分明显低于C型患者(P<0．05)。结论北方地区以c基因型和C2亚型为主。B基因型患者的年龄明显小于C基因型。B和c基因型(Cl和C2亚型)患者的肝脏炎症和病毒量之间无差别。B基因型患者的肝脏炎症和纤维化评分明显小于C型患者。

English Abstract:

Objective To determine the distribution and virologic characteristics of HBV genotypes,sub-type and possible association with the severity of liver disease. Methods 884 patients infected withHBV were enrolled from 8 provinces in China. HBV genotype and sub-type was determined, using PCR-RFLP method. Results The most common HBV genotypes were B (20.77%)and C (78.22%)but only1 patient showed genotypes D. We found sub-type Ba in patients with genotype B, Cl and C2 sub-type inpatients with genotype C. Genotype C(83.62%)and sub-type C2(90.32%)were predominant innorthern China. Patients with genotype B were much younger than those with genotype C. There was nosignificant difference between patients with sub-type Cl and C2. There was no significant difference in liverfunction and serum HBV-DNA load between patients with genotype B and C,or between patients with sub-type Cl and C2. However, hepatic inflammation and fibrosis score in patients with genotype B weresignificantly lower than those with genotype C. Conclusion There were no significantly differences in liverfunction and HBV-DNA load between patients with genotype B and C,or between patients with sub-typeCL and C2. Hepatic inflammation and fibrosis score in patients with genotype B were significantly lowerthan those with genotype C. Genotype C/sub-type C2 were preponderance in northern China.

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