| 黄从刚,李睿,左慧萍,王争艳,何荣华,邹永光.急性心肌梗死危险因素和促发因素的青年人与中老年人暴露率比较[J].Chinese journal of Epidemiology,2007,28(3):282-285 |
| 急性心肌梗死危险因素和促发因素的青年人与中老年人暴露率比较 |
| Comparison of the expOSure rates of risk factors and inducing factors of acute myocardial infarction between younger aged adults |
| Received:August 24, 2006 Revised:August 24, 2006 |
| DOI： |
| KeyWord: 心肌梗死 危险因素 促发因素 心肌缺血叠加效应 青年人 |
| English Key Word: Myocardialinfarction Risk factor Inducing factor Myocardialischemia accumuiation effect Younger adults |
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| Abstract: |
| 目的结合新近发现的冠心病危险因素，总结青年人急性心肌梗死(AMI)的临床特点，探讨早发AMI的可能机制。方法回顾性对照分析青年组(≤40岁，37例)和中老年组(≥50岁，105例)两组AMI患者与非冠心病患者的危险因素和促发因素的暴露率，并行冠脉造影检查。结果两组AMI患者危险因素分布存在差异，青年组表现为吸烟、血脂异常、家族史、C反应蛋白(CRP)、血浆纤维蛋白原(Fig)暴露率明显增多，中老年组为高血压、吸烟、血脂异常、糖尿病、CRP、F培、同型半胱氨酸(P结论青年人早发AMI可能与促发因素聚集有关，多种促发因素同时存在通过心肌缺血叠加效应导致动脉粥样硬化(As)患者和非As患者发生AMI。 |
| English Abstract: |
| Objective To study the clinical characteristics of acute myocardialinfarction(AMI) among younger adults and to explore the possibIe mechanisms of early myocardialinfarction，combined with the newly discovered risk factors of coronary heart disease. Methods Data on comparative analysis to the exposure rates of the risk factors and inducing factors of non—CAI)patients with two groups of AMI patients including younger adults group(≤40 years old) and aged adults group(≥50 years old).Cbronary angiography was applied.Results There were differences noticed between the frequencies of risk factors of the two AMI groups. In younger adults group the exposure rates of smoking，hyperlipidemia，positive family history，C—reactive protein(CRP)and fibrinogen were markedly higher，while in elderly group the exposure rates of hypertension，smoking hyperlipidemia，diabetes，CRP，fibrinogen and homocysteine(HCY) were markedly higher(P<0.05).Although the clustermg status of risk factors of the younger adult group was not higher than that of the elderly group. There were obvious inducing factors before the patients weremattacked by AMI and the inducing factors inclined to cluster，which had obvious dose-reaction relationships with the occurrence of AMI in young people.Conclusion Early AMI of younger adults might relate to the clustering status of inducing factors.The coexistence of several kinds of inducing factors was resulted in the noccurrence of AMI of the atherosclerosis(As) and non—As patients by means of myocardial ischemia accumulation effect. |
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