| 翟祥军,汪华,朱凤才,余家席,陈胤忠,邱祥鹏,顾善坤,刘社兰,秦黎明,梁争论,庄辉.江苏省农村地区儿童乙型肝炎疫苗免疫效果及其影响因素研究[J].Chinese journal of Epidemiology,2007,28(4):322-325 |
| 江苏省农村地区儿童乙型肝炎疫苗免疫效果及其影响因素研究 |
| Study on the efficacy of hepatitis B viruse vaccination and its influencing factors among children in rural area of Jiangsu province |
| Received:February 16, 2007 |
| DOI： |
| KeyWord: 乙型肝炎疫苗 乙型肝炎表面抗原 母婴传播 |
| English Key Word: Hepatitis B vaccine Hepatms B surface antigen Mother-to-infant transmissi。n |
| FundProject:国家“f五”科技攻关课题资助项目(2004BA718802) |
| Author Name | Affiliation | E-mail | | ZHAI Xiangjun | Jiangsu Center for Disease Control and Prevention, Nanjing 210009, China | | | WANG Hua | Jiangsu Center for Disease Control and Prevention, Nanjing 210009, China | | | ZHU Fengcai | Jiangsu Center for Disease Control and Prevention, Nanjing 210009, China | jszfc@vip．sina．com | | YU Jiaxi | 徐州市疾病预防控制中心 | | | CHEN Yinzhong | 盐城市疾病预防控制中心 | | | QIU Xiangpeng | 沛县疾病预防控制中心 | | | GU ShanKun | 滨海县疾病预防控制中心 | | | LIU Shelan | Jiangsu Center for Disease Control and Prevention, Nanjing 210009, China | | | QIN Liming | Jiangsu Center for Disease Control and Prevention, Nanjing 210009, China | | | LIANG Zhenglun | 中国药品生物制品检定所 | | | ZHUANG Hui | 北京大学医学部微生物学系 | |
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| Abstract: |
| 目的<\b> 探讨江苏省农村地区儿童接种乙型肝炎(乙肝)疫苗后免疫效果及其影响因素.方法<\b> 采用多阶段分层随机整群抽样方法<\b>,抽取江苏省农村地区在实施乙肝疫苗计划免疫后出生的农村儿童为研究对象,检测HBsAg、抗-HBs标志,对抗-HBs阴转儿童进行不同种类疫苗的加强免疫,并分析HBsAg阳性儿童乙肝病毒(HBV)感染的危险因素.结果<\b> 2522名1～7岁儿童中HBsAg阳性率在0.28%～1.28%之间,抗-HBs随年龄增加而逐渐下降,由1岁时的76.7%降至7岁时的45.5%;出生时未及时接种乙肝疫苗的儿童的HBV感染率显著高于及时接种儿童(1.4%∶0.5%,P=0.031);应用不同剂量疫苗加强免疫后,抗-HBs阳转率均为90%以上.结论<\b> 江苏省农村地区计划免疫适龄儿童人群的HBsAg阳性率为0.28%～1.28%,平均为0.8%,儿童中HBV感染主要为母婴传播,并与未及时接种乙肝疫苗有关. |
| English Abstract: |
| objectjve<\b> To evaluate the efficacy of hepatitis B viruse(HBV)vaccination and its influencing factors among children in rural area of Jiangsu province.Methods<\b> Twenty-five hundred and
twenty-two children born after 1998 in rural area were selected as the study population using multistage cluster sampling method.HBsAg and anti.HBs were detected by enzyme linked immunoassay(ELISA) and radio-immunoassay(RIA)，respectively.Anti-HBs negative children were b00sted using different hepatit_is B vaccines and the efficacy was compared.Factors causing HBV infection in HBsAg positive children were also investigated.Results<\b> HBsAg positive rates in 1-7 year 01ds were 0.28％一1.28％，and the anti-HBs positive rates decreased from 76.7％to 45.5％.The HBsAg p。sitive rate in children not timely vaccinated was significantly higher than those with HBV vaccine injection within 24 hours after birth(1.4％ vs.0.5％，P=0.031).More than 90％of the anti-HBs negative children had protective level of anti-HBs after boosted with HBV vaccine.Conclusion<\b> HBsAg positive rate in children born after 1998 in rural area of Jiangsu province decreased significantly，with an average of 0.8％.The reason for HBsAg carriage in
children might be attributed to mother-to-infant transmission or not timely HBV vaccination. |
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