广西壮族自治区133例艾滋病患者抗病毒治疗效果评价

李韩平; 刘伟; 刘海霞; 梁淑家; 鲍作义; 刘永建; 庄道民; 刘思扬; 李林; 李敬云

Abstract

李韩平,刘伟,刘海霞,梁淑家,鲍作义,刘永建,庄道民,刘思扬,李林,李敬云.广西壮族自治区133例艾滋病患者抗病毒治疗效果评价[J].Chinese journal of Epidemiology,2007,28(4):338-342

广西壮族自治区133例艾滋病患者抗病毒治疗效果评价

Study on the antiviral therapy program among people with human immunodeficiency virus in Guangxi Zhuang Authority

Received:June 30, 2006

DOI：

KeyWord: 艾滋病抗病毒治疗耐药性毒株

English Key Word: Acquired immunedeficiency syndrom Antiviral therapy Drug resistance strain

FundProject:国家“F五”科技攻关课题资助项目(2004BA719A05)；卫生部艾滋病防治应用性研究资助项目(wA2003—02)

Author Name	Affiliation	E-mail
LI Hanping	The State Key Laboratory of Phathogen and Bioseurity，Institute of Microbiology and Epidemiology， Academy of Military Medical Sciences, Beijing 100071, China
LIU Wei	广西壮族自治区疾病预防控制中心
LIU Haixia	首都医科大学附属北京佑安医院
LIANG Shujia	广西壮族自治区疾病预防控制中心
BAO Zuoyi	The State Key Laboratory of Phathogen and Bioseurity，Institute of Microbiology and Epidemiology， Academy of Military Medical Sciences, Beijing 100071, China
LIU Yongjian	The State Key Laboratory of Phathogen and Bioseurity，Institute of Microbiology and Epidemiology， Academy of Military Medical Sciences, Beijing 100071, China
ZHUANG Daomin	The State Key Laboratory of Phathogen and Bioseurity，Institute of Microbiology and Epidemiology， Academy of Military Medical Sciences, Beijing 100071, China
LIU Siyang	The State Key Laboratory of Phathogen and Bioseurity，Institute of Microbiology and Epidemiology， Academy of Military Medical Sciences, Beijing 100071, China
LI Lin	The State Key Laboratory of Phathogen and Bioseurity，Institute of Microbiology and Epidemiology， Academy of Military Medical Sciences, Beijing 100071, China
LI Jingyun	The State Key Laboratory of Phathogen and Bioseurity，Institute of Microbiology and Epidemiology， Academy of Military Medical Sciences, Beijing 100071, China	lqy@nic．bmi．an．cn

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Abstract:

目的<\b> 了解广西壮族自治区部分艾滋病感染者抗病毒治疗后免疫功能恢复与病毒抑制效果.方法<\b> 2004年7月至2005年10月在广西南宁与柳州地区招募接受抗病毒治疗时间＞3个月的艾滋病患者133例,并在同一地区选择感染时间接近、尚未接受抗病毒治疗感染者58例作为对照.通过专业问卷,了解抗病毒治疗患者服药依从性;采集患者的EDTA抗凝静脉血,通过CD4^{+<\sup> T淋巴细胞计数与病毒载量测定,了解免疫重建与病毒抑制情况;通过基因型耐药性检测分析抗病毒治疗人群与未治疗人群中HIV-1耐药性毒株的发生情况.结果<\b> 在接受抗病毒治疗人群中,约有70.69%患者的CD4^{+<\sup> T淋巴细胞明显回升,23.28%患者CD4^{+<\sup> T细胞未有明显变化,6.03%的患者CD4 T细胞计数明显下降;比较治疗与未治疗人群病毒载量水平,接受治疗人群载量对数均值(1.834±0.853)显著低于未治疗人群(3.621±1.121)(P＜0.05),治疗人群中67.91%的患者病毒载量水平低于检测限;治疗人群中耐药性发生率(11.90%)与未治疗组(11.63%)无明显差异.结论<\b> 广西地区实施的抗病毒治疗对免疫系统重建、体内病毒的抑制具有明显作用;耐药性流行情况在治疗与未治疗人群中无明显差异.}}}

English Abstract:

Objective<\b> To explore the reconstituti。n of immune function and viral suppressioncondition and to analyze the occurrence of drug resistance HIV.1 va“ants and its prevalence after using}IAART in Guangxi Aut。nomy Region.Me￡hods From July 2004 to October 2005，133 HIV infectedindividuals who had received HA ART for more than three months were recruited，and 58 infected personswith no antiviral therapv were selected as contr01s.Questionnaire was used to collect information about theadherence of HAART therapy.Immune reconstruction and viral suppress conditions were obtained byCD4^{+<\sup> counts and viral load and RT-PCR were used to amplify the PR and RT regions of HIV一1 genomewhile HIV一1 drug resistance rates were analvzed to show the occurrence and prevalence in both treated andnaive patients.ResuIts In terms of CD4^{+<\sup> T cell counts：70.69％of the treated patients showed obviousincrease and 23.28％had no apparent change but 6.03％of them went down.70.48％of the patientswho had received antiviral theraDv more than 3 months had their viral load 10wer than the Iow detectablelimitation.When comparing the log of viral 10ad between treated and untreated cohort，the mean value ofthe treated was obviouslv less than the untreated(PConclusion<\b> The antiviral therapy beingused in Guangxi region，had achieved obvious cffect on the reconstruction of immune system and thesuppression of viral replication in vivo under good adherence while the occurrence of drug-resistant HIVstrain did not show obvious differencc between treated and naive patient groups.}}

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