| 余华丽,常昭瑞,张立实,张静,李振军,徐建国,冉陆.国家监测点2005年志贺菌菌型分布和药敏结果分析[J].Chinese journal of Epidemiology,2007,28(4):370-373 |
| 国家监测点2005年志贺菌菌型分布和药敏结果分析 |
| Analysis on the status of Shigella spp antimicrobial resistance through data from the National Shigellosis Surveillance System in China, in 2005 |
| Received:September 22, 2006 |
| DOI： |
| KeyWord: 志贺菌 抗生素 药敏实验 血清分型 监测 |
| English Key Word: Shigella spp Antimicrobial susceptibility test serotyping surVeillance |
| FundProject:中国疾病预防控制中心肠道传染病监测与预警经费资助项目 |
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| Abstract: |
| 目的<\b> 分析2005年国家监测点志贺菌菌型分布和药敏结果<\b>.方法<\b> 用WHONET 5.4软件对国家监测点的志贺菌药敏试验结果<\b>(K-B纸片扩散法)进行统计分析.结果<\b> ①福氏志贺菌最为常见,占75.5%;其次为宋内志贺菌,占24.4%.②志贺菌分离株对四环素和氨苄西林的耐药率均超过90.0%;对头孢噻肟的耐药率最低,为6.1%.③志贺菌分离株的多重耐药情况较为严重,五重及其以上的多重耐药率占54.9%.④不同省份志贺菌优势菌型和耐药谱有差异.结论<\b> 志贺菌的耐药现状不容乐观,三代头孢菌素仍是治疗志贺菌感染的较好选择.志贺菌优势菌型和药敏特征需要连续监测,才能及时了解病原特点. |
| English Abstract: |
| Objective<\b> The Ministry of Public Health released the National surveillance project on Shigellosis in August，2005.This study was to reveal the antimicmbial resistance status of Shigella isolates through the National Shigellosis Surveillance System in 2005 in China，sO as to provide evidence for the development of surveiUance，prevention and cure of Shigenosis.Methods<\b> An the lab assistants received training from Chinese Center fOr Disease ControI and Prevention.The project prescribed the unifOrm experimentation，quality control method，reagent，etc.Disc diffusion test(K-B)was carried out，following the CLSI methods.Data were analyzed by WHONET 5.4 software.Results<\b> (1)3 serotypes were identified and S.flexneri was common that accounted for 75.5％ of aH Shigella isolates followed by 24.4％of S.flexneri，but only 1 strain of S.dysenteriae was separated.(2)The resistant rates to tetracycline and ampiciUin in Shigella spp were quite high，as over 90.0％.However，the resistant rate to Cefotaxime was the lowest， only 6.1％.The resistant rates were di“erent between semtypeS with the resistant rates of S.／zBz”Pri to ampicillin，ampicillin／clavulanate and ciprofloxacin were higher than t}lose of S.sonnei(P<0.001).(3)The multiple-antibiotic-resistance status in Shigella spp was quite serious and the reSistant rate to five and more antimicrobials was 54.9％.The moSt common resistant pattems were seen on ampicillin，nalidixin，tetracycline and sulfamethoxazole.(4)There were SOme differences in subtypes and antimicrobial resistance among different prOvinces.Conclusion<\b> Cefotaxime seemed the best in curing Shigellosis at the clinic level.Programs regarding monitoring subtypeS and antimicrobiaJ reSistance of Shigella should be in a continuous manner so as to understand the pathogens timely and to contr01 the disease pertinently. |
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