食管癌易感性与STK15基因Phe31Ile多态性的关联研究

王娜; 王贵英; 郭炜; 董秀娟; 李琰

Abstract

王娜,王贵英,郭炜,董秀娟,李琰.食管癌易感性与STK15基因Phe31Ile多态性的关联研究[J].Chinese journal of Epidemiology,2007,28(4):394-397

食管癌易感性与STK15基因Phe31Ile多态性的关联研究

Study on the association between STK15 Phe31Ile polymorphisms and esophageal squamous cell carcinoma

Received:October 25, 2006

DOI：

KeyWord: 食管鳞状细胞癌发病易感性 sTKl5基因单核苷酸多态性

English Key Word: Esophageal squamous cell carcinoma Gene susceptibility sTKl5 gene Single nucleotide polymorphism

FundProject:河北省普通高等学校强势特色学科资助项目

Author Name	Affiliation	E-mail
WANG Na	Division of Molecular Biology, The Fourth Hospital o Hebei Medical University, Shijiazhuang 050011, China
WANG Guiying	050011, 石家庄, 河北医科大学第四医院外二科
GUO Wei	Division of Molecular Biology, The Fourth Hospital o Hebei Medical University, Shijiazhuang 050011, China
DONG Xiujuan	Division of Molecular Biology, The Fourth Hospital o Hebei Medical University, Shijiazhuang 050011, China
LI Yan	Division of Molecular Biology, The Fourth Hospital o Hebei Medical University, Shijiazhuang 050011, China	lykxl962@yahoo．com．cn

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Abstract:

目的<\b> 研究STK15基因Phe31Ile(91T→A)单核苷酸多态性(SNP)与河北省涉县人群食管鳞状细胞癌(ESCC)发病易感性的关系.方法<\b> 采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法<\b>检测了涉县296例ESCC患者和302例健康对照STK15 Phe31Ile(91T→A)SNP的基因型.结果<\b> 吸烟及上消化道肿瘤(UGIC)阳性家族史均能显著增加ESCC的患病风险(OR值分别为1.68和1.77,95% CI分别为1.34～2.10和1.44～2.19).STK15 Phe31Ile三种基因型(Phe/Phe、Phe/Ile、Ile/Ile)频率在ESCC患者组中分别为11.5%、34.8%和53.7%,与健康对照组(11.9%、36.8%和51.3%)相比差异无统计学意义(χ^{2<\sup>=0.35,P=0.84).以Phe/Phe基因型作参照,Phe/Ile基因型及Ile/Ile基因型分别与其相比,均未增加ESCC的发病风险(OR值分别为0.98和1.09,95% CI分别为0.57～1.69和0.65～1.82).根据性别、吸烟状况及上消化道肿瘤(UGIC)家族史进行分层分析,也未发现病例组与对照组之间的差异有统计学意义.结论<\b> STK15基因Phe31Ile(91T→A)SNP可能与河北涉县人群ESCC的患病风险无关.}

English Abstract:

Objective<\b> To study the relation between sin91e nucleotide polymorphism(sNP)at the 91T→A(Phe31 Ile)poSition。f the STKl5 gene and the susceptibility of esophageaI squarnous cell carcinoma (ESCC)in She county-a ESCC high incidence region in North China.Methods<\b> Polymerase-chain reaction(PCR)-rest“ction fragment length polym。rphism(RFLP)analysis was used to detect the genotypes ofSTKl5 Phe31Ile(91T-’A)SNP，and the samples came fmm 296 ESCC patients and 302 healthy controls.Results<\b> The risk of ESCC significantly increased in the group whjch had been smoking or having a family history of upper gastrointestinal cancer(UGIC)(the DR=1.68 and 1.77，95％CJ：1.34-2.10 and 1.44.2.19，respectively).Rates of the three genotypes(Phe／Phe，Phe／Ile，Ile／Ile)of the sTKl5 Phe31Ile (91T→A)SNPs in ESCC patients were 11.5％，34.8％and 53.7％，respectively，and were not significantly different from that in the healthy gr。up(11.9％，36.8％and 51.3％)(χ^{2<\sup>=0.35，P=0.84).when compared to Phe／Phe genotype，Phe／11e and Ile／Ile of STKl5 91T→A(Phe31Ile)did not show effect on the risk of ESCC according to the odds ratio results which were 0.98(95％C工：0.57.1.69)and 1.09 (0.65.1.82)respectively.STKl5 91T-+A(Phe31Ile)SNP also did rlot significantly influence on the development of ESCC even the samples were stratified by sex，smoking status and family history of upper gastmintestinal cancer.Conclusion<\b> The STKl5 Phe31Ile(91T→A)polymorphisms seemed irrelevant with the risk of ESCC in She country.}

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