| 潘品良,刘震,张永宏,龙小山,吴昊,蒋岩.HIV/HCV共感染对HIV一1生物学特性影响的研究[J].Chinese journal of Epidemiology,2007,28(6):589-592 |
| HIV/HCV共感染对HIV一1生物学特性影响的研究 |
| Study on the influence of biological characteristics to HIV/HCV co-infection among HIV infected iIlegal blood donors in China |
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| DOI： |
| KeyWord: 人类免疫缺陷病毒 丙型肝炎病毒 共感染 生物学特性 |
| English Key Word: Human immunodeficiency virus Hepatitis virus C Co一infection Biological characteristicS |
| FundProject:国家“十五”科技攻关课题基金资助项目(2001BA705801) |
| Author Name | Affiliation | E-mail | | PAN Pin-liang | National Centre for AIDS/STD prevention1 and control, Chinese Centre for Disease Control and Prevention, Beijing 100050, China | | | LIU Zhen | National Centre for AIDS/STD prevention1 and control, Chinese Centre for Disease Control and Prevention, Beijing 100050, China | | | ZHANG Yong-hong | 佑安医院 | | | LOMG Xiao-shan | National Centre for AIDS/STD prevention1 and control, Chinese Centre for Disease Control and Prevention, Beijing 100050, China | | | WU Hao | 佑安医院 | | | JIANG Yan | National Centre for AIDS/STD prevention1 and control, Chinese Centre for Disease Control and Prevention, Beijing 100050, China | jiangyan03@263.net |
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| Abstract: |
| 目的研究有偿献血人群HIv/Hcv共感染对HIV一1基因离散率、病毒载量、cD4+T淋巴细胞等生物学特性影响。方法扩增HIV一1 env基因C2～V3区, Clustal W和Phylip软件计算基因离散率, NASBA方法检测HIV-l病毒载量, 采用coulter公司的Epics XL流式细胞计数仪检测CD4+细胞数, 用SPSS软件f检验分析H1V/HCV共感染对HIV一1生物学特性的影响。结果HCV共感染与非共感染人群的HIV一1平均基因离散率为7.95%、15.73%(P<0.001), 平均病毒载量为4.61、4.45(P=0.522), 平均CD4+T淋巴细胞数为308、251(P=0.161)。结论该有偿献血人群中HIV/HCV共感染对HIV一1基因离散率有影响, 而对病毒载量、CD4+T淋巴细胞无影响。 |
| English Abstract: |
| Objective To study the influence of biological characteristics on HCV／HIV co-infection, including HIV-1 sequence distance, HIV-1 viral load and CD4十count.Methods HIV一1 sequence distance was calculated by Clustal Wand Phylip software while HIV一1 viral load being tested by NASBA and CD4十count was tested using Epics XL of Coulter. Significance was determined by t-test using SPSS 12.0. Results The mean HIV-1 genetic distances were 7-95％and 15.73％(PConclusion Data showed that in the study group, the HIV/HCV co-infection had an influence on the HIV sequence distance, but did not have major impact on HIV.1 viral load and their mean CD4十T count. |
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