| 周红霞,仇小强,张志勇,黄腾,甘文烨,曾小云,谢志春,GiraudouxP.生态流行病学概念[J].Chinese journal of Epidemiology,2007,28(7):712-714 |
| 生态流行病学概念 |
| Eco-epidemiology: newly discovered infectious diseases; basic concepts |
| Received:August 31, 2006 |
| DOI： |
| KeyWord: 生态流行病学 新发现传染病 概念 |
| English Key Word: Eco-epidemiology Emerging disease Concepts |
| FundProject: |
| Author Name | Affiliation | | ZHOU Hong-xia | 广西医科大学公共卫生学院流行病学教研室, 南宁 530021 | | QIU Xiao-qiang | 广西医科大学公共卫生学院流行病学教研室, 南宁 530021 | | ZHANG Zhi-yong | 广西医科大学公共卫生学院流行病学教研室, 南宁 530021 | | HUANG Teng | 广西医科大学公共卫生学院流行病学教研室, 南宁 530021 | | GAN Wen-yu | 广西医科大学公共卫生学院流行病学教研室, 南宁 530021 | | ZENG Xiao-yun | 广西医科大学公共卫生学院流行病学教研室, 南宁 530021 | | XIE Zhi-chun | 广西医科大学公共卫生学院流行病学教研室, 南宁 530021 | | Giraudoux P | Department of Environmental Biology, University of Franche-Comte, Place Leclerc, 25030 Besancon, France |
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| Abstract: |
| 医学在21世纪已得到极大的发展,但疾病对人类的威胁并未减弱,慢性疾病发病率居高不下,新发现传染病又开始袭击人类.这种威胁迫使流行病学重新思考自己固有的传统方法与现代疾病模式的矛盾,努力寻求新的方法来应对21世纪人类健康的敌人[1]. |
| English Abstract: |
| Objective Recently studies showed infections of Chlamydia pneumoniae (Cp), Helicobacter pylori (Hp) and cytomegalovirus (CMV) played roles in the development of atherosclerosis. The aim of this study was to study relationship between infection of Cp, Hp and CMV, systemic inflammatiom and coronary artery disease (CAD).Methods Fourty-five patients with at least one coronary artery stenosis 50% and 33 control subjects with negative coronary angiography were recuited for this case-control study from May 2000 to October 2001. Antibodies against Cp, Hp and CMV were measured and serum C-reactive protein (CRP) levels determined for each case. CRP level 0.8 mg/dl was defined at elevated CRP level.Results The prevalence of Cp IgG, Hp IgG or Hp IgA antibody was associated with CAD (P=0.017, P 0.001, P=0.009). After adjustment for age, gender, smoking, hypertension, hyperlipidemia and diabetes, the association was still seen. Mean CRP value was significantly higher in patients with CAD, compared to those without CAD (P 0.001). Multivariate analysis showed statistical significance (P=0.03). Elevated levels of CRP were found to be an important parameter for CAD (P=0.032). The prevalence of Cp IgG antibody, Hp IgG and CMV IgG antibody all showed no association with elevated levels of CRP (P=0.391, P=0.253, P=0.724). The ratio of elevated levels of serum basic CRP in the group with IgG antibodies to 3 pathogens was 32.1% while in the group with IgG antibodies to ≤2 pathogens it was 14.9%. But with no significante difference between the two (P=0.078).Conclusions Two chronic infections, Cp and Hp, might increase the risk of CAD. There was no association of CMV infection with CAD. C-reactive protein was an independent parameter of CAD, but the increased systemic inflammation in CAD did not seem to be related to aforesaid infection. |
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