| 鲍彦平,李霓,王鹤,乔友林.中国妇女子宫颈人乳头瘤病毒型别分布的Meta分析[J].Chinese journal of Epidemiology,2007,28(10):941-946 |
| 中国妇女子宫颈人乳头瘤病毒型别分布的Meta分析 |
| Study on the distribution of human papillomavirus types in cervix among Chinese women:a Meta-analysis |
| Received:June 28, 2007 |
| DOI： |
| KeyWord: 宫颈肿瘤 人乳头瘤病毒 型别分布 Meta分析 |
| English Key Word: Cervix neoplasms Human papillomavirus Type-distribution Meta-analysis |
| FundProject:世界卫生组织曰际癌症研究所资助项目(FI/92/3-11 CHN) |
| Author Name | Affiliation | E-mail | | Bao Yanping | Department of Cancer Epidemiology, Cancer Institute Hospital, Chinese Academy of Medical Science, Beijing 100021, China | | | Li Ni | 中国医科大学公共卫生学院流行病教研室 | | | Wang He | Department of Cancer Epidemiology, Cancer Institute Hospital, Chinese Academy of Medical Science, Beijing 100021, China | | | Qiao Youlin | Department of Cancer Epidemiology, Cancer Institute Hospital, Chinese Academy of Medical Science, Beijing 100021, China | qiaoy@public.bta.net.cn |
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| Abstract: |
| 目的 了解中国妇女不同子宫颈病变中人乳头瘤病毒(HPV)型别分布特点，估计HPVl6/18型预防性疫苗的应用前景。方法 在18个用PCR方法榆测子官颈HPV型别分布的国内外研究中，共包括1335例浸润性子宫颈癌(ICC)、394例子宫颈鳞状上皮内高度病变(HSIL)、381例子宫颈鳞状上皮内低度病变(LSIL)和2584名正常对照组。建立非条件logistic回归模型，计算中国不同子宫颈病变的HPv总感染率，并计算18种HPV(6、16、18、31、33，35、39、45、51、52、56、58、59、66、68、70、73和82)型别感染率。结果 在ICC、HSIL、LSIL和正常对照中，总HPV调整感染率分别为82.7%、88.5%、69.3%和13.1%。所有宫颈状态中，HPVl6型为最常见的HPV型别，在ICC中，占第2、3位的依次为HPVl8型和58型；在HSIL、LSIL和正常组中分别为HPV58型和52型。在ICC中，HPVl6、18、58、52和31型是最常见的5种HPV型别。HPVl6/18型在ICC、HSIL、LSIL和正常子宫颈中的感染率依次为69.6%、59.1%、32.3%和4.4%。结论估计HPVl6/18型疫苗对中国的子宫颈癌有高达69.6%的预防作用，除HPVl6/18型外，HPV58型是中国妇女中的优势HPV型别，在新一代HPV疫苗开发中应该予以足够重视，中国需要有标准统一的多中心HPV型别分布的研究。 |
| English Abstract: |
| Objective To explore the distribution the tyes-of human papillomavirus (HPV) in cervical biopsy tissue or exfoliated cell specimen of Chinese women and to estimate the perspective of HPV Prophylactic vaccine in China.Methods A total of 18 studies using polymerase chain reaction to detect HPV types were included in this Meta-analysis.There were 1335,394,381 and 2584 cases included in invasive cervical cancer(ICC),high-grade squamous intraepithelial lesions (HSIL),low-grade squamaus intraepithelial lesions (LSIL) and normal group respectively.The overall HPV prevalence was estimated by adjusting the variables using unconditional multiple logistic regression model.HPV type-specific HPV prevalence rates of 18 types including HPV6 ,16 ,18 ,31,33 ,35 ,39 ,45 ,51,52,56 ,58 ,59 ,66,68 ,70,73 and 82 were estimated,after stratified by cervical lesion of Chinese women.Results In ICC,HSIL,LS1L and normal group,the overall HPV prevalence rates were 82.7%,88.5%,69.3% and 13.1% respectively ,and the HPV16 type-specific prevalence were 61.9%,46.7%,21.0% and 3.1%.HPV 16 was the predominant type in all cervical lesion specimen followed by HPV18 and 58 in ICC group,then HPV58 and 52 in HSIL,LSIL and normal.The estimated HPV16/18-positive #ractioas were 69.6%，59.1%，32.3% and 4.4% respectively in ICC,HSIL and norntal.Data from the Meta-analysis showed that the top five common HPV types in ICC women were HYV16,18,58,52 and 31 which contributed for 82.9% of the ICC.Thus the HPV16,18,31，33,35，45,52 and 58 were accounted for 87.7% ICC:in China mainland.Conclusion The proportional impact of HPV16/18 vaccine on ICC was estimated as high as 69.6% in China.HPV58 seemed the priority HPV type and should be emphasized enough to be included in the development of new generation HPV vaccine.However,mare uniform standardized multi center studies were necessary to get more exact figure about HPV distribution in China. |
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